What are the signs and symptoms of systemic-onset juvenile idiopathic arthritis (JIA)?

Updated: Jul 25, 2019
  • Author: David D Sherry, MD; Chief Editor: Lawrence K Jung, MD  more...
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Systemic-onset JIA is characterized by spiking fevers, typically occurring once or twice each day, at about the same time of day, with temperature returning to normal or below normal. The fever pattern is very useful because infections, Kawasaki disease, and malignancy usually do not have such a predictable pattern.

Systemic-onset JIA is usually accompanied by an evanescent rash (lasting a few hours), which is typically nonpruritic, macular, and salmon colored on the trunk and extremities. Occasionally, the rash is extremely pruritic and resistant to antihistamine treatment.

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