What is the role of lab testing in the diagnosis of juvenile idiopathic arthritis (JIA)?

Updated: Jul 25, 2019
  • Author: David D Sherry, MD; Chief Editor: Lawrence K Jung, MD  more...
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Diagnosis of JIA is based on the history and physical examination findings. When physical findings do not document definite arthritis, further evaluation is warranted. Laboratory studies that may be considered include the following:

  • Inflammatory markers: Erythrocyte sedimentation rate (ESR) or CRP level

  • Complete blood count (CBC) and metabolic panel

  • Liver function tests and assessment of renal function with serum creatinine levels

  • Antinuclear antibody (ANA) testing

  • Rheumatoid factor (RF) and anti–cyclic citrullinated peptide (CCP) antibody

  • Additional studies: Total protein, albumin, fibrinogen, ferritin, D-dimer, angiotensin-converting enzyme (ACE), antistreptolysin 0 (AS0), anti-DNAse B, urinalysis

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