What is the role of biopsy in the workup of pediatric mixed connective-tissue disorder (MCTD)?

Updated: Oct 24, 2018
  • Author: Marisa S Klein-Gitelman, MD, MPH; Chief Editor: Lawrence K Jung, MD  more...
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See the list below:

  • Perform tissue biopsy as indicated to evaluate disease severity.

  • In particular, kidney biopsy should be considered when hypocomplementemia is present, even if initial urine evaluations are negative, because some studies suggest that patients with mixed connective tissue disease can have nonclinical nephritis.

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