Which physical findings are characteristic of pediatric mixed connective-tissue disorder (MCTD)?

Updated: Oct 24, 2018
  • Author: Marisa S Klein-Gitelman, MD, MPH; Chief Editor: Lawrence K Jung, MD  more...
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Detailed physical examination is critical. [10]

  • Classification criteria other than autoantibody status rely on clinical examination and diagnostic tests.

  • Consider the following to make the diagnosis:

    • Alopecia

    • Pleuritic chest pain

    • Pericardial rub

    • Arthritis

    • Raynaud phenomenon

    • Malar rash

    • Petechial rash

    • Muscle weakness

    • Swollen hands (especially dorsal surface)

    • Trigeminal neuropathy

    • Acrosclerosis or sclerodermatous skin changes

    • Epigastric tenderness

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