What are the signs and symptoms of pediatric mixed connective-tissue disorder (MCTD)?

Updated: Oct 24, 2018
  • Author: Marisa S Klein-Gitelman, MD, MPH; Chief Editor: Lawrence K Jung, MD  more...
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  • The most frequent presentation of mixed connective tissue disease (MCTD) is a child with polyarthritis, general malaise, and Raynaud phenomenon.

  • Patients may present with the following:

    • Sclerodermatous skin (usually limited to fingers but can be more extensive).

    • Sausage-shaped fingers

    • Proximal muscle weakness

    • Rash (finger ulcers or pits, Gottren papules)

    • Vasculitic rashes (usually palpable purpuric rashes)

    • Dysphagia

    • Gastroesophageal reflux disease (GERD) symptoms

    • Fever

    • Rheumatoid nodules

    • Lymphadenopathy

    • Alopecia

    • Telangiectasia

    • Headache

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