What are the sequence of events in the development of pneumomediastinum (PM)?

Updated: Feb 26, 2019
  • Author: Patrick L Carolan, MD; Chief Editor: Girish D Sharma, MD, FCCP, FAAP  more...
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Answer

The Macklin effect, first described in 1939, highlights the sequence of events in the development of pneumomediastinum as follows: (1) alveolar rupture, (2) air dissection along the bronchovascular sheath, and (3) free air reaching the mediastinum.


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