Which medications in the drug class Enzymes, Pancreatic are used in the treatment of Cystic Fibrosis?

Updated: Oct 30, 2018
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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Answer

Enzymes, Pancreatic

These agents aid digestion when the pancreas is malfunctioning. Current pancreatic enzyme preparations are derived from porcine extracts and contain various proportions of lipase, amylase, and protease. Most of the preparations are available in multiple strengths.

A particular dose is prescribed based on clinical symptoms and age and weight and then modified according to the clinical response. Usually, the dose of pancreatic enzymes should not exceed 2000 U/kg/meal of lipase. The novel preparation TheraCLEC-Total, a highly purified microbiologically-derived enzyme preparation, is under investigation in clinical trials.

Pancrelipase (Creon, Pancreaze, Ultresa, Zenpep)

These enteric-coated pancreatic enzyme microspheres contain various amounts of lipase, protease, and amylase. Pancrelipase assists in the digestion of protein, starch, and fat.


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