Which medications in the drug class Bronchodilators are used in the treatment of Cystic Fibrosis?

Updated: Oct 22, 2019
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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Answer

Bronchodilators

Albuterol provides selective agonistic action on beta2-adrenoceptors. Stimulation of adenyl cyclase results in smooth muscle relaxation of the bronchi, uterus, and skeletal muscle.

Inhaled beta2-agonists are often administered before chest physical therapy for airway clearance. They also are indicated when clinical evidence of bronchial hyperresponsiveness exists. In children with CF, the use of bronchodilators must be evaluated. Children with bronchiectasis may have a paradoxic bronchodilatation in response to beta-adrenergic agents. Pulmonary function testing before and after bronchodilators is suggested to avoid these counterproductive effects.

Albuterol (AccuNeb, ProAir, Proventil HFA, VoSpire ER, Ventolin HFA)

Albuterol is the most commonly used bronchodilating agent. It is available in multiple dosage forms (eg, solution for nebulization, metered-dose inhaler, PO solution). Typically, 2.5 mg of albuterol nebulizer solution is used either in premixed solution with isotonic sodium chloride solution or 0.5 mL of albuterol solution is mixed with 3 mL of 0.9% NaCl and administered before chest physical therapy.


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