What are the treatment options for cystic fibrosis (CF) comorbid with diabetes?

Updated: Oct 22, 2019
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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Answer

Pancreatic tissue damage leads to diabetes mellitus in 8-12% of CF patients older than 25 years. In the Cystic Fibrosis-Related Diabetes Therapy (CFRDT) Trial, Moran et al found that among patients with CF-–related diabetes without fasting hyperglycemia, insulin therapy improved and sustained body mass index (BMI). [50] Patients treated with repaglinide had an initial significant BMI gain; however, after 6 months, it declined, and no difference was noticed at 1 year.


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