What are negative prognostic factors in cystic fibrosis (CF)?

Updated: Oct 22, 2019
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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Answer

A review of 6750 deaths due to cystic fibrosis in England and Wales from 1959-2008 reported that female sex and low socioeconomic status are associated with poorer outcomes than male sex and high socioeconomic status. [23]

A study of 1517 patients with cystic fibrosis who were registered with the UK Cystic Fibrosis Registry showed that lower muscle mass, shorter stature, and a low body mass index are associated with increased mortality. [24]

In a prospective observational study of 3142 patients from the Cystic Fibrosis Foundation Registry, weight for age percentile at 4 years of age was associated with improved clinical outcomes including lung function, fewer complications of cystic fibrosis and better survival through the age of 18. [25]


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