How does the prevalence and clinical presentation of cystic fibrosis (CF) vary by race?

Updated: Oct 22, 2019
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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The distribution of CFTR mutations varies according to the background of patients; for example, ΔF508 is the most common mutation found in the white population of northern European origin. Variability in clinical features between people of different races with same genotype has not been reported.

Clinical manifestations are similar in black and white populations, except that a poorer nutritional status is observed in black patients. Black patients with cystic fibrosis are younger at diagnosis and have poorer nutritional status and pulmonary function than white patients with cystic fibrosis. Whether this is genetic or due to socioeconomic factors is unclear; low socioeconomic status is associated with significantly worse pulmonary outcomes in patients with cystic fibrosis.

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