What is the prevalence of cystic fibrosis (CF) in the US?

Updated: Oct 30, 2018
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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Answer

Cystic fibrosis is an autosomal-recessive disease. Its estimated heterozygote frequency in white people is up to 1 in 20. Each offspring of 2 heterozygote parents has a 25% chance of developing cystic fibrosis.

Cystic fibrosis is the most common lethal hereditary disease in the white population. In the United States, the prevalence is as follows:

  • Whites of northern European origin - 1 case per 3,200-3,500 population

  • Hispanics - 1 case per 9,200-9,500 population

  • African Americans - 1 case per 15,000-17,000 population

  • Asian Americans - 1 case per 31,000 population

The worldwide incidence varies from 1 per 377 live births in parts of England to 1 per 90,000 Asian live births in Hawaii. The higher frequency in Asian American or African American populations compared with native Asians or Africans reflects white admixture. [18]


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