Chemico-biological interactions

(ISSN: 0009-2797, 1872-7786)

Chemico-biological interactions's Latest Table of Contents

2016 - 255

  • Editorial: Promising approaches to identify DILI drugs. 
  • Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse. 
  • The cytochrome P450 inhibitor SKF-525A disrupts autophagy in primary rat hepatocytes. 
  • In��vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries. 
  • In��vitro model systems to investigate bile salt export pump (BSEP) activity and drug interactions: A review. 
  • Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. 
  • Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles. 
  • Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity. 
  • Drugs of abuse and addiction: A slippery slope toward liver injury. 
  • Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development. 
  • Oxidative stress markers, secondary bile acids and sulfated bile acids classify the clinical liver injury type: Promising diagnostic biomarkers for cholestasis. 
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