-
The Laboratory Diagnosis of Paroxysmal Nocturnal Hemoglobinuria (PNH)
This review presents a history of diagnostic laboratory tests for paroxysmal nocturnal hemoglobinuria, a rare acquired stem cell disorder.
January 12, 2012
-
Blood Sample Processing
This report from a panel of leading clinical pathologists focuses on recent key issues surrounding blood sample processing, including a push for smaller sample size, automated systems, and more.
January 05, 2012
-
33-year-old Liver Transplant Recipient Returns From Hunting Trip in Sudan With Intermittent Fevers and Gross Hematuria
Given this patient's symptoms and history of recent African travel, there were several possible viruses which could be responsible for his hemorrhagic fever. What did lab tests reveal?
December 29, 2011
-
In Silico Evaluation and Testing of Fluorescence In Situ Hybridization 16S rRNA Probes for Staphylococcus aureus
This review evaluates six different online computational tools for assessment of candidate FISH probes for S. aureus. How accurate are they?
December 22, 2011
-
Setting Up a Standardized Peripheral Blood Mononuclear Cells Processing Laboratory to Support Multi-center HIV/AIDS Vaccine and Intervention Trials
This article describes the challenges of creating a sustainable cell processing lab for HIV and AIDS-related clinical trials at a rural field site in Africa.
December 15, 2011
-
Falsely Elevated Parathyroid Hormone-related Protein (PTH-RP) in a Patient With Hypercalcemia and Renal Failure
Hypercalcemia is often associated with cancer, but this patient with renal failure and hypercalcemia showed no obvious malignancy. What was the cause of his elevated PTH-RP?
December 09, 2011
-
Delayed Hemolytic Transfusion Reaction Without Detectable Autoantibodies or Alloantibodies
In this unusual case, a sickle-cell patient experienced a delayed hemolytic transfusion reaction without the usually observed autoantibodies or alloantibodies. What factors may have played a role?
November 21, 2011
-
(1-3)-Beta-D-Glucan Assay
Invasive fungal infections are associated with significantly high morbidity and mortality. This review highlights a new assay that can be used to aid in the diagnosis of these serious infections.
November 14, 2011
-
New Contrast Stain for the Rapid Diagnosis of Dermatophytosis and Pityriasis Versicolor
The authors describe a rapid, reliable, and easy to interpret diagnostic method for dermatophyte infection and pityriasis versicolor utilizing a new staining agent.
November 08, 2011
-
Hematologic Markers of Influenza A H1N1 for Early Laboratory Diagnosis and Treatment Assessment
Early laboratory diagnosis of influenza A H1N1 infection would be beneficial to improving the survival rate. Is there a reliable hematologic marker that can be considered diagnostic of this disease?
October 27, 2011
-
Digital Pathology: A Regulatory Overview
With digital pathology now entering clinical laboratories, it is crucial for laboratory professionals to understand the regulatory requirements and how to best implement them.
October 13, 2011
-
Kids in America: Newborn Screening for Cystic Fibrosis
Every state in the US has now adopted newborn screening protocols for cystic fibrosis. This overview discusses and evaluates the various testing algorithms and protocols which are being used.
September 29, 2011
-
Evaluation of Four Qualitative Third-Generation HIV Antibody Assays and the Fourth-Generation Abbott HIV Ag/Ab Combo Test
This review compares four third-generation rapid HIV tests to the fourth-generation Abbott HIV Ag/Ab Combo assay. Which is the most useful for screening HIV-infected patients?
September 22, 2011
-
Systemic Sclerosis - An Update
This review provides an update on systemic sclerosis, including epidemiology, survival, clinical features, pathophysiology, immunobiology, and the importance of early diagnosis and tailored therapy.
September 15, 2011
-
Automated Lymphocyte Counts vs Manual Lymphocyte Counts in Chronic Lymphocytic Leukemia Patients
Can automated differential leukocyte counts be used in place of manual differential leukocyte counts in chronic lymphocytic leukemia patients?
September 08, 2011
-
Resistant Herpes Simplex Virus Infection and HIV
HSV infections often present atypically in HIV coinfected patients, and routine anti-herpetic viral agents may be ineffective. This case study examines the issues of HSV/HIV coinfection.
August 16, 2011
-
Standardized Assessment of the HER2 Status in Breast Cancer by Immunohistochemistry
Assessment of HER2 status in breast cancer is a critical element in the determination of therapy. This article discuss practical approaches to standardization of HER2 testing by immunohistochemistry.
August 09, 2011
-
Diagnostic and Clinical Relevance of HBV Mutations
Hepatitis B continues to be a serious public health issue, with emerging HBV mutations confounding diagnosis and leading to vaccine failure and resistance to antiviral agents.
August 02, 2011
-
Gaining Efficiency in the Laboratory -- Automated Body Fluid Cell Counts: Evaluation of the Body Fluid Application on the Sysmex XE-5000 Hematology Analyzer
The Sysmex XE-5000 is the first fully automated hematology analyzer to have a dedicated body fluid mode. How well does it perform?
July 11, 2011
-
Management of Inpatient Hyperglycemia
Hyperglycemia occurs frequently in hospitalized patients, and not only in those with diagnosed diabetes. What is the best therapeutic course of action in these patients?
July 05, 2011
