Tenofovir Disoproxil Fumarate, Emtricitabine, and Efavirenz Compared With Zidovudine/Lamivudine and Efavirenz in Treatment-Naive Patients: 144-Week Analysis CME

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Release Date: March 3, 2008Valid for credit through March 3, 2009
Credits Available
Physicians - maximum of 1.0 AMA PRA Category 1 Credit(s) for physicians

Contents of This CME Activity
    To participate in this internet activity: (1) review the target audience, learning objectives, and author disclosures; (2) study the education content; (3) take the post-test and/or complete the evaluation; (4) view/print certificate View details.

    Tenofovir Disoproxil Fumarate, Emtricitabine, and Efavirenz Compared With Zidovudine/Lamivudine and Efavirenz in Treatment-Naive Patients: 144-Week Analysis
    Jose R. Arribas, MD
    Anton L. Pozniak, MD
    Joel E. Gallant, MD, MPH
    Edwin DeJesus, MD
    Brian Gazzard, MD
    Rafael E. Campo, MD
    Shan-Shan Chen, MPH
    Damian McColl, PhD
    Charles B. Holmes, MD, MPH
    Jeffrey Enejosa, MD
    John J. Toole, MD, PhD
    Andrew K. Cheng, MD, PhD

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Learning Objectives

Upon completion of this activity, participants will be able to:

  1. Compare the viral load by HIV RNA level in patients with HIV given tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) vs zidovudine/lamivudine (ZDV/3TC) with efavirenz (EFV) over 144 weeks of treatment
  2. Compare the CD4 count 144 weeks and less than 144 weeks in patients with HIV given TDF/FTC vs ZDV/3TC with EFV over 144 weeks
  3. Compare the resistance pattern to EFV in patients with HIV given TDF/FTC vs ZDV/3TC with EFV over 144 weeks
  4. Compare the discontinuation rate in patients with HIV given TDF/FTC vs ZDV/3TC with EFV over 144 weeks
  5. Compare adverse effects in HIV patients given TDF/FTC vs ZDV/3TC with EFV over 144 weeks
Authors and Disclosures

Jose R. Arribas, MD
Disclosure: Jose R. Arribas, MD, has disclosed that he has received consulting fees from Abbott Laboratories, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Tibotec, and Roche.


Anton L. Pozniak, MD
Disclosure: Anton L. Pozniak, MD, has disclosed that he has received consulting fees, educational and travel grants from Gilead Sciences, GlaxoSmithKline, Roche, Tibotec, and Bristol-Myers Squibb.


Joel E. Gallant, MD, MPH
Disclosure: Joel E. Gallant, MD, MPH, has disclosed that he has received consulting fees, grant/research support, or honoraria from Abbott Laboratories, Boehringer Ingelheim, Roche Pharmaceuticals, Gilead Sciences, GlaxoSmithKline, Merck, Tibotec, Panacos, Monogram Biosciences, Schering-Plough, Pfizer, and Bristol-Myers Squibb.


Edwin DeJesus, MD
Disclosure: Edwin DeJesus, MD, has disclosed that he has received consulting fees or research support from Gilead Sciences, GlaxoSmithKline, Roche Pharmaceuticals, and Bristol-Myers Squibb.


Brian Gazzard, MD
Disclosure: Brian Gazzard, MD, has disclosed that he has received consulting fees from Gilead Sciences, GlaxoSmithKline, and Bristol-Myers Squibb.


Rafael E. Campo, MD
Disclosure: Rafael E. Campo, MD, has disclosed that he is a clinical investigator, clinical grant recipient, and speaker for Gilead Sciences, GlaxoSmithKline, Abbott Laboratories, Merck, Pfizer, and Bristol-Myers Squibb.


Shan-Shan Chen, MPH
Disclosure: Shan-Shan Chen, MPH, has disclosed no relevant financial relationships.


Damian McColl, PhD
Disclosure: Damian McColl, PhD, has disclosed no relevant financial relationships.


Charles B. Holmes, MD, MPH
Disclosure: Charles B. Holmes, MD, MPH, has disclosed no relevant financial relationships.


Jeffrey Enejosa, MD
Disclosure: Jeffrey Enejosa, MD, has disclosed no relevant financial relationships.


John J. Toole, MD, PhD
Disclosure: John J. Toole, MD, PhD, has disclosed no relevant financial relationships.


Andrew K. Cheng, MD, PhD
Disclosure: Andrew K. Cheng, MD, PhD, has disclosed no relevant financial relationships.


Désirée Lie, MD, MSEd
Disclosure: Désirée Lie, MD, MSEd, has disclosed no relevant financial relationships.


Paul A. Volberding, MD
Disclosure: Paul A. Volberding, MD, has disclosed that he has served as an advisor or consultant to Bristol-Myers Squibb, Gilead, Schering, Merck, GlaxoSmithKline, TaiMed, and Pfizer. Dr. Volberding has also disclosed that he has received grants from GlaxoSmithKline.


 
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Medscape, LLC designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

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