Medscape Conference Coverage, based on selected sessions at the:
American College of Cardiology 55th Annual Scientific Session
March 11 - 14, 2006, Atlanta, Georgia

This activity is not sanctioned by, nor a part of, the American College of Cardiology.


Also On This Page:Topic OverviewsLate-Breaking TrialsConference News
Topic Overviews
Highlights of the American College of Cardiology 55th Annual Scientific Session CME
Physicians - up to 1.0 AMA PRA Category 1 credit(s)
New Trials of Antithrombotic Therapy for ACS -- ACC 2006
Christopher P. Cannon, MD
Latest Data on Treating Atrial Fibrillation -- From Ablation to Adjunctive Drugs
Eric N. Prystowsky, MD

Interventional Corner
This year, the ACC introduced the Innovation in Intervention: i2 Summit 2006 -- the first meeting-within-a-meeting at the ACC specifically geared toward interventional cardiology. The Summit, which was cosponsored by the Society for Cardiovascular Angiography and Interventions (SCAI), provided a forum for experts to discuss the latest advances in this constantly evolving field. However, it was not only the i2 Summit that featured topics on interventional cardiology; research in this field was also a prominent focus during the main ACC Sessions. With our coverage of the ACC 2006 meeting and i2 Summit, Medscape Cardiology is inaugurating a special section -- Interventional Corner -- led by Luis Gruberg, MD, highlighting research and clinical advances in this all-important arena. Below are selected summaries with viewpoints from the late-breaking trial presentations on interventional cardiology held during both meetings.
Conference Review - Imaging in Intervention: Emerging Technologies
As described in this session, advances in imaging technology will enable us to understand the pathologic changes and therefore provide a wider range of therapeutic alternatives to our patients.
Antithrombotic Therapies
ACUITY and ACUITY Timing: Heparin, GP IIb/IIIa inhibitors (Upstream vs Deferred Use), and Bivalirudin -- Managing Moderate- to High-Risk ACS Patients
The results from ACUITY have widespread implications that are likely to change the way adjuvant anticoagulation is given to ACS patients who undergo PCI.
OASIS-6: Sixth Organization to Assess Strategies in Acute Ischemic Syndromes -- Effects of Fondaparinux in STEMI Patients
These are important results that may improve the outcomes of STEMI patients, especially those who do not undergo primary PCI as a reperfusion strategy.
ExTRACT-TIMI 25: Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment
The present study provides important data that may change current guidelines for the management of STEMI patients treated with thrombolytic therapy.
ISAR-REACT 2: Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 2
Should abciximab be added to the treatment regimen of high-risk ACS patients undergoing PCI after pretreatment with clopidogrel?
Drug-Eluting Stents/Stent Systems
STENT: Strategic Transcatheter Evaluation of New Therapies -- Paclitaxel- vs Sirolimus-Eluting Stents in Diabetic Patients
These results will likely only fuel the ongoing debate about the superiority of one stent over the other.
TAXUS-V ISR: Paclitaxel-Eluting Stents vs Vascular Brachytherapy for the Treatment of In-stent Restenosis Within Bare-Metal Stents
Is it time to retire vascular brachytherapy as the gold-standard treatment for in-stent restenosis?
PROGRESS-AMS: Coronary Stenting With Magnesium-Alloy Absorbable Metal Stent
First-in-man trial results suggest a magnesium-alloy absorbable stent may overcome some of the limitations associated with conventional stenting.
BASKET-LATE: Late Clinical Events Related to Late Stent Thrombosis After Stopping Clopidogrel: Drug-Eluting vs Bare-Metal Stenting
The results of this small study and the conclusions reached by the authors are certainly a cause for concern.
CAPTURE: Evaluation of Carotid Stenting in Community Practice
Further analysis of these data will certainly help us understand the best therapeutic options for patients with symptomatic and asymptomatic carotid artery stenosis.
Late-Breaking Trials
ASTEROID: A Study To Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden
Using intravascular ultrasound to assess atherosclerotic vessel segments, high-dose statin therapy has been shown for possibly the first time to cause actual regression of atheroma volume -- although this result is short-term and does not prove clinical benefit.
CHARISMA: Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance
Dual antiplatelet therapy with aspirin + clopidogrel is beneficial for secondary prevention, but apparently not primary prevention, according to CHARISMA -- but read the societies' comments before modifying treatment regimens!
MIST: Migraine Intervention with STARflex Technology Trial
Does catheter-based closure of patent foramen ovale (PFO) cure migraine headaches?
Heart Outcomes Prevention Evaluation (HOPE) 2 -- Homocysteine Lowering in Stable Chronic Vascular Disease
Homocysteine continues to be regarded as a possible marker of cardiovascular disease risk -- and one of the follow-up studies from HOPE explores whether lowering serum homocysteine levels will have beneficial effects on that risk.
TROPHY: Trial Of Preventing Hypertension
JNC 7 redefined the JNC VI "high normal" BP category as "prehypertension" -- TROPHY asked what happens if prehypertensive BP levels are treated with drugs, and is this to be recommended?
The Pediatric Randomized Carvedilol Trial in Children with Heart Failure
Carvedilol has a proven track record in adult heart failure (HF) patients and a presumed one in children -- but this first clinical trial in pediatric HF suggests that perhaps that presumption is not evidence-based.
PRIMO-CABG II: Pexelizumab for the Reduction of Infarction and Mortality in Coronary Artery Bypass Graft Surgery II
The use of a specifically designed drug that can block the detrimental effects of complement activation seems logical. But...
Conference News
Discharge Use of Carvedilol Reduces Mortality 3/17/06
[Medscape Medical News]
Novel Renin Inhibitor Lowers Blood Pressure 3/17/06
[Medscape Medical News]
CRP Levels Increase After Statin Withdrawal 3/15/06
[Medscape Medical News]

 
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