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Temporal Lobe Epilepsy: The Current State of Knowledge CME
Chairperson: Daniel H. Lowenstein, MD; Faculty: Jerome Engel, Jr, MD, PhD; Orrin Devinsky, MD; Pratik Mukherjee, MD, PhD; Robert S. Sloviter, PhD; Marc A. Dichter, MD, PhD; Samuel Wiebe, MD, MSc, FRCPC
Disclosures

Release Date: February 24, 2004; Valid for credit through February 24, 2005

This activity has expired.
CME in this activity indicates that it was developed according to ACCME guidelines and was certified for credit by one or more accredited CME or CE providers. Medscape cannot attest to the timeliness of expired CME activities.


Sponsored by the American Epilepsy Society

This CME activity is based on transcripts and slides of presentations as delivered by the faculty at the 23rd Annual Merritt-Putnam Symposium, "Temporal Lobe Epilepsy: The Current State of Knowledge" held at the Hynes Convention Center in Boston, MA on December 6, 2003 during the American Epilepsy Society Annual Meeting.

Physicians should not claim credit for this activity if credit was previously claimed for the symposium on which this Internet activity is based. Estimated time to complete this educational activity: 2 hours

Contents of This CME Activity
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  1. An Overview of the Clinical Problem
    by Jerome Engel, Jr, MD, PhD
    Introduction to Temporal Lobe Epilepsy
    Mesial Temporal Lobe Epilepsy: History and Neurologic Examination
    Mesial Temporal Lobe Epilepsy: Pathophysiology
    Mesial Temporal Lobe Epilepsy: Etiology and Natural History
    Mesial Temporal Lobe Epilepsy: Diagnosis and Conclusions
    Mesial Temporal Lobe Epilepsy: Diagnosis and Conclusions (cont'd)

  2. The Normal Function of the Temporal Lobe
    by Orrin Devinsky, MD
    Temporal Lobe Functions
    Localizing Functions and Seizures
    White Matter: Intrinsic and U Fibers
    White Matter: Projection and Association
    White Matter and the Myth of the Silent Cortex
    The Amygdala
    Hippocampus and Memory
    Lateral and Basal Cortex and Other Brain Areas
    Temporal Pole and Closing Thoughts

  3. Imaging the Temporal Lobe
    by Pratik Mukherjee, MD, PhD
    Imaging: Objectives
    Sensitivity of Standard Magnetic Resonance Imaging
    Magnetic Resonance Imaging: Various Protocols in 1 Patient
    Magnetic Resonance Image Protocols in Various Patients
    Conventional Magnetic Resonance Imaging and Ancillary Imaging Methods
    Imaging in Cortical Dysplasia
    Future Directions With Magnetic Resonance Imaging
    Anatomic, Physiologic and Metabolic Imaging
    Conclusions

  4. Pathophysiology of TLE at the Level of Networks
    by Robert S. Sloviter, PhD
    Clues, Not Causal Relationships
    Pathophysiology: Differing Views
    Hypotheses: Hyperexcitability and Mossy Fiber Sprouting
    Untested Predictions: Granule Cell Responses in Rat Studies
    Conclusions

  5. Pathophysiology of Human TLE at the Level of Cells and Synapses
    by Marc A. Dichter, MD, PhD
    Introduction to Temporal Lobe Epilepsy Pathology
    The Normal Temporal Lobe
    Hyperexcitability and Brain Injuries: Anatomic Changes
    Physiologic Changes and Reaction to Neurologic Injury
    Temporal Lobe Seizures: Epileptogenic Zones
    Localization of Fast Ripples
    Ictogenesis and Potassium
    Ictogenesis, Inhibition, and Epileptogenesis

  6. Treatment Options for TLE and Long-term Outcomes
    by Samuel Wiebe, MD, MSc, FRCPC
    Introduction and Objectives
    Important Patient Outcomes
    Drug Therapy in Refractory Temporal Lobe Epilepsy
    Surgical Therapy: Randomized Trials in Epilepsy
    Trial Data: Surgical vs Medical
    Practice Parameter: Overview
    Practice Parameter: Data and Recommendations
    Long-term Surgical Outcomes: Meta-analysis
    Long-term Outcomes: Medical and Surgical
    Conclusions

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The American Epilepsy Society is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The American Epilepsy Society designates this educational activity for a maximum of 2.0 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.
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