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Optimizing Efficacy and Tolerability of Antidepressant Therapy: Does Selectivity of Action Matter? CME
Chairperson: Michael E. Thase, MD; Faculty: Pedro L. Delgado, MD; Justine M. Kent, MD; Andrew A. Nierenberg, MD
Disclosures

Release Date: August 21, 2003Valid for credit through August 21, 2004

This activity has expired.
CME in this activity indicates that it was developed according to ACCME guidelines and was certified for credit by one or more accredited CME or CE providers. Medscape cannot attest to the timeliness of expired CME activities.


This program is based on an Industry-Supported Symposium presented at the American Psychiatric Association 156th Annual Meeting. The APA was not involved in, and received no commercial support for, the development of this product and does not award CME credit for this program. This CME activity is based on transcripts and slides of presentations as delivered by the faculty at the "Optimizing Efficacy and Tolerability of Antidepressant Therapy: Does Selectivity of Action Matter?" symposium held at the San Francisco Marriott in San Francisco, California on May 17, 2003.

Contents of This CME Activity
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    Slides with transcript and RealAudio:

  1. Welcome and Introduction
    by Michael E. Thase, MD
    Introduction

  2. The Alphabet Soup of Antidepressant Pharmacology: From TCAs and MAOIs to SSRIs, SNRIs, and Beyond
    by Pedro L. Delgado, MD
    Antidepressants and Their Binding Affinities
    Antidepressants and Their Neurotransmitters
    Neurotransmitter Depletion Studies
    Understanding Behavior: Cellular Interactions in the Brain
    Neuronal Sensitization and Arborization
    An Overview of What's Happening in Depression

  3. Efficacy of Newer Antidepressants
    by Michael E. Thase, MD
    Assessing Efficacy of Antidepressants: Clinician and FDA Perspectives
    Detecting Meaningful Differences in Antidepressants
    Use of Meta-Analyses and Pooled Analyses to Assess Antidepressants
    Venlafaxine for Depression
    Duloxetine for Depression
    Bupropion for Depression
    Nefazodone, Mirtazapine for Depression

  4. SSRIs and Beyond: Spectrum of Efficacy of Newer Antidepressants
    by Justine M. Kent, MD
    Beyond Depression With Antidepressants
    Antidepressants in Generalized Anxiety Disorder
    Antidepressants in Panic Disorder
    Antidepressants in Social Anxiety Disorder
    Antidepressants in Other Psychiatric Disorders
    Conclusions

  5. Generally Well Tolerated: Comparative Adverse Event Profiles of Newer Antidepressants
    by Andrew A. Nierenberg, MD
    The Myths About Side Effects
    Side Effects and Compliance
    Education Improves Compliance
    Side Effects and Relation to Time
    Side Effects With Various Antidepressants
    Other Side Effects With Selective Serotonin Reuptake Inhibitors
    Asthenia, Apathy, and Late-Onset Effects
    Side Effects Associated With Venlafaxine
    Side Effects Associated With Bupropion and Other Antidepressants
    Conclusions

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Legal Disclaimer
The material presented here does not necessarily reflect the views of Medscape, The Postgraduate Institute for Medicine, the companies providing educational grants or the authors and writers. These materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. All readers and continuing education participants should verify all information and consult a qualified healthcare professional before treating patients or utilizing any therapeutic product discussed in this educational activity.

 
Copyright © 2003 the Postgraduate Institute for Medicine.



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