Lipids and Metabolic

heartwire News

  • ACC No Plaque Reduction Seen With Mimetic HDL Agent in ACS The study in patients with ACS did nothing to support the HDL hypothesis, although the bioengineered agent meant to promote reverse cholesterol transport had been promising in prior studies.
  • Coronary Artery Calcium Score Identifies More African Americans Who Need Statins The coronary artery calcium (CAC) score can identify African Americans who would benefit from statin therapy but would not be included based on current US Preventive Services Task Force (USPSTF) recommendations, according to results from the Jackson Heart Study.
  • ACC 'Suggestion' of Brain Changes on Statins by fMRI in STOMP Despite few differences at cognitive testing for patients on atorvastatin vs placebo in the STOMP substudy, "small but significant" neuronal changes were seen on statins, their meaning unclear.
  • Statins Increase Diabetes Risk by up to 50% in Older Women A new analysis homing in on elderly women finds increased risk of diabetes in users of statins vs nonusers and suggests doctors pay heed to careful risk/benefit assessment in this patient population.

Perspective

  • Migraine Linked to Cervical Artery Dissection This is the second large study to find such an association, but the first to identify it as being stronger in young patients. Dr Laurie Barclay shares the results.
  • Targets for Treating Renal Aging Dr O'Sullivan, the lead author of a study published in the Journal of the American Society of Nephrology, discusses his findings and theories on the causes and consequences of renal aging.
  • Assessing Stroke Risk in Adult Congenital Heart Disease   Drs Lyle, Ammash, and McLeod discuss risk stratification for stroke in adults with complex congenital heart disease and how to choose between warfarin or the direct oral anticoagulants in the absence of data.
  • Alt FOURIER: Diet and Exercise vs PCSK9i?   If Dr Walton-Shirley were designing the next trial on PCSK9 inhibitors, she'd include a Mediterranean diet and exercise arm. She and Dr Mandrola ponder alternative uses of our healthcare dollars.