Vyvanse | Industry information for Vyvanse

Vyvanse dosage and administration

Now available in 6 dosage strengths

For pediatric or adult patients either starting treatment or switching from another medication, 30 mg once daily in the morning is the recommended dose
Dose may be titrated in 10-mg or 20-mg increments in intervals of approximately 1 week
The maximum recommended dose is 70 mg/day
Capsule may be taken whole with or without food, or may be opened and the entire contents dissolved in a glass of water and consumed immediately¹

*IMS National Prescription Audit (NPA), December 2008, since pediatric availability

IMPORTANT SAFETY INFORMATION

Vyvanse is indicated for the treatment of ADHD. Efficacy based on two controlled trials in children aged 6 to 12 and one controlled trial in adults.

Vyvanse should not be taken by patients who have:

advanced arteriosclerosis
symptomatic cardiovascular disease
moderate to severe hypertension
hyperthyroidism
known hypersensitivity or idiosyncrasy to sympathomimetic amines
agitated states
glaucoma
a history of drug abuse
or during or within 14 days after treatment with monoamine oxidase inhibitors (MAOIs)

Sudden death has been reported in association with CNS stimulant treatment at usual doses in children and adolescents with structural cardiac abnormalities or other serious heart problems. Sudden death, stroke, and myocardial infarction have been reported in adults taking stimulant drugs at usual doses in ADHD. Physicians should take a careful patient history, including family history, and physical exam, to assess the presence of cardiac disease. Patients who report symptoms of cardiac disease such as exertional chest pain and unexplained syncope should be promptly evaluated. Use with caution in patients whose underlying medical condition might be affected by increases in blood pressure or heart rate.
New psychosis, mania, aggression, growth suppression, and visual disturbances have been associated with the use of stimulants. Use with caution in patients with a history of psychosis, seizures or EEG abnormalities, bipolar disorder, or depression. Growth monitoring is advised during prolonged treatment.
Amphetamines have a high potential for abuse. Administration of amphetamines for prolonged periods of time may lead to drug dependence. Particular attention should be paid to the possibility of subjects obtaining amphetamines for non-therapeutic uses or distribution to others and the drugs should be prescribed or dispensed sparingly. Misuse of amphetamine may cause sudden death and serious cardiovascular adverse events.
The most common adverse events reported in clinical studies of Vyvanse were: pediatric – decreased appetite, insomnia, abdominal pain, and irritability; adult – decreased appetite, insomnia, and dry mouth.

Please see accompanying Full Prescribing Information, including Boxed Warning.

Vyvanse Medication Guide

VYV-00241 02/09

Reference

Vyvanse [package insert], Wayne, PA: Shire US Inc; 2008.

For Children

For Adults

For Children and Adults

Vyvanse dosage and administration

Now available in 6 dosage strengths