« Return to Medscape

Developed under the direction and sponsorship of Lilly USA, LLC.


Deepen your understanding of some of the differences between CDK4 & 6 with this educational video featuring Sean Buchanan, PhD, Research Fellow & Group Leader, Oncology Research at Eli Lilly & Company.

The answer is False.
Preclinical evidence suggests that the roles of CDK4 and CDK6 may differ in both normal tissues and malignancies, depending on the cellular context.1-9

References: 1. Martin J, Hunt SL, Dubus P, et al. Oncogene. 2003;22:5261-5269. 2. Jirawatnotai S, Aziyu A, Osmundson EC, et al. J Biol Chem. 2004:279:51100-51106. 3. Scheicher R, Hoelbl-Kovacic A, Bellutti F, et al. Blood. 2015;125:90-101. 4. Hu MG, Deshpande A, Enoas M, et al. Cancer Res. 2009;69:810-818. 5. Reddy HKDL, Mettus RV, Rane SG, Graña X, Litvin J, Reddy EP. Cancer Res. 2005;65:10174-10178. 6. Yu Q, Sicinska E, Geng Y, et al. Cancer Cell. 2006;9:23-32. 7. Matushansky I, Radparvar F, Skoultchi AI. Oncogene. 2003;22:4143-4149. 8. Grigoriadis A, Mackay A, Reis-Filho JS, et al. Breast Cancer Res. 2006;8(5):R56. 9. Lucas JJ, Domenico J, Gelfand EW. Mol Cancer Res. 2004;2:105-114.

©Lilly USA, LLC 2017. All rights reserved. This site is intended for US healthcare professionals only.
PP-ON-US-1566 02/2017