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CDK4 & 6 EXPLORATION

  • 5 OF THE DIFFERENCES BETWEEN CDK4 & 6

    CLICK TO COMPARE

  • BREAST CANCER

    CDK4

    Required for mammary tumorigenesis in certain animal models; loss of CDK4 is not compensated for by presence of CDK61,2

    CDK6

    Levels are decreased in many breast tumors and breast cancer-derived cell lines3

  • EFFECT ON STEROID HORMONE PRODUCTION

    CDK4

    Upregulates enzymes responsible for steroid hormone production in a breast cancer cell line4

    CDK6

    Downregulates enzymes responsible for steroid hormone production in a breast cancer cell line4

  • PROLIFERATION

    CDK4

    Plays a role in the proliferation of pancreatic and pituitary endocrine cells5,6

    CDK6

    Regulates proliferation of T lymphocytes7 and hematopoietic stem cells8

  • MALIGNANCIES

    CDK4

    More likely to have preferential activity in epithelial cancers9

    CDK6

    More likely to have preferential activity in mesenchymal cancers9

  • LEUKEMIC CELL DIFFERENTIATION

    CDK4

    Does not block differentiation in leukemic cells10

    CDK6

    Blocks differentiation in leukemic cells10

The answer is False.
Preclinical evidence suggests that the opposite is true: CDK4 is more likely to have preferential activity in epithelial cancers, whereas CDK6 is more likely to have preferential activity in mesenchymal cancers.9

References: 1. Reddy HKDL, Mettus RV, Rane SG, Graña X, Litvin J, Reddy EP. Cancer Res. 2005;65:10174-10178. 2. Yu Q, Sicinska E, Geng Y, et al. Cancer Cell. 2006;9:23-32. 3. Lucas JJ, Domenico J, Gelfand EW. Mol Cancer Res. 2004;2:105-114. 4. Jia Y, Domenico J, Swasey C, Wang M, Gelfand EW, Lucas JJ. PLoS ONE. 2014;9:e97448. 5. Martín J, Hunt SL, Dubus P, et al. Oncogene. 2003;22:5261-5269. 6. Jirawatnotai S, Aziyu A, Osmundson EC, et al. J Biol Chem. 2004;279:51100-51106. 7. Hu MG, Deshpande A, Enos M, et al. Cancer Res. 2009;69:810-818. 8. Scheicher R, Hoelbl-Kovacic A, Bellutti F, et al. Blood. 2015;125:90-101. 9. Malumbres M, Barbacid M. Nat Rev Cancer. 2009;9:153-166. 10. Matushansky I, Radparvar F, Skoultchi AI. Oncogene. 2003;22:4143-4149.

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