Chronic Leukemia Perspective

 
 
  • Lenalidomide Trial KO'd: A Blow to CLL Patients?   Dr. Bruce Cheson discusses the clinical ramifications of the decision to halt the ORIGIN trial, which compared lenalidomide vs chlorambucil in previously untreated elderly patients with CLL.
  • Abandoning PETs in Lymphoma   Drs. Bruce Cheson and Gilles Salles discuss lymphoma highlights from ASCO 2013 on new targeted agents, potential combinations, and indications that surveillance requires few scans.
  • Blood's Up -- and So Are the Outcomes   Dr. Bruce Cheson highlights noteworthy studies in lymphoma, chronic lymphocytic leukemia, and multiple myeloma being presented at ASCO 2013.
  • New Therapy Unleashes 'Serial Killer' Cells in Leukemia Adoptive immunotherapy is providing exciting preliminary results in leukemia patients. Leading researcher Dr. Carl June explains the therapy and its potential application to other cancers.
  • ASH 2012: More Fuel for the Fire   Dr. Bruce Cheson highlights studies that should prove controversial and practice-changing, as well as new drugs that expand treatment options.
  • Preparing Immunocompromised Patient for International Travel Find out how to prepare your patients with disease- or drug-related immune suppression for travel abroad.
  • CLL Genomics: Converting a Prognostic Factor Into a Target TP53 deletion is known to be an adverse prognostic factor in patients with chronic lymphocytic leukemia. Dr. Maurie Markman looks at how it can be used as a target for therapy.
  • New Agents, Durable Responses in CLL   Dr. John Gribben highlights important data in chronic lymphocytic leukemia presented at the 2012 annual congress of the European Hematology Association.
  • Lymphoma: Radiation Therapy for DLCL?   Dr. Martin Dreyling reviews the highlights of the lymphoma studies presented at the 2012 annual meeting of the European Hematology Association.
  • Blood Cancers: What to Look for in Leukemia   Dr. Bruce Cheson highlights noteworthy studies, new drugs, and impressive data in ALL, CLL, and CML that will be discussed at ASCO® 2012.
  • Another 'CLL Case' Cured   Dr. Bruce Cheson discusses a patient referral that serves as a reminder that healthy persons can harbor markers of disease when no disease is present.
  • Great New Drugs Will Be Harder to Come By   Dr. Bruce Cheson discusses the Cheson Rule for New Drug Approval, which states (rather paradoxically) that the more effective a drug is, the more it negatively affects future drug development.
  • A Dickensian CLL Story   Drs. Bruce Cheson and Clemens Wendtner visit ghosts of CLL treatment past, present, and future.
  • ASH Preview: A Look at What's Hot   Dr. Bruce Cheson highlights the hot topics at ASH, singling out emerging drugs, rediscovered therapies, and ongoing controversies.
  • Gene Therapy: A New Option for CLL?   Dr. Bruce Cheson reports on a provocative case published in The New England Journal of Medicine suggesting that gene therapy may offer CLL patients an effective alternative to chemotherapy.
  • Alemtuzumab Combo: Not the Ticket for CLL?   Dr. Bruce Cheson says a new German study of alemtuzumab and fludarabine in relapsed CLL is somewhat irrelevant and the therapy significantly more toxic compared with other combination therapies.
  • A New Therapeutic Target for Hairy Cell Leukemia Dr. Maurie Markman reviews a recent paper identifying a druggable BRAF mutation in patients with hairy cell leukemia.
  • CLL in the Elderly: Is the Game Plan Changing? Prof. Peter Hillmen, an expert in blood cancers, speaks about treatments available for elderly patients with CLL, focusing on options that offer deeper remission vs those that are better tolerated.
  • Blood Cancer: New Drugs and Old Problems   Important studies in the treatment of blood cancers presented at ASCO® are discussed by Drs. John Leonard and Richard Stone.
  • ASH Wrap-up: Lymphoma and Leukemia -- The Take-Home Message   Drs. Bruce Cheson, Jorge Cortes, and John Leonard give an overview of the findings on lymphoma and leukemia presented at ASH 2010.
 
 
 
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