Cardiomyopathy News

 
 
  • Revascularization Can Boost Diastolic Function The finding in patients with chronic, ischemic, low-LVEF cardiomyopathy and hibernating myocardium on dobutamine-echo imaging is said to support the use of viability studies in working up patients with ischemic heart disease.
  • Contemporary Views of HCM The reports include insights about stratification for risk of sudden death and about structural features that echocardiography may often miss but can be seen at magnetic resonance imaging and appear to distinguish inherited from hypertensive hypertrophic cardiomyopathy.
  • Stress Cardiomyopathy Precipitated by Routine Procedures Exposure to catecholamines and beta agonists during routine procedures and diagnostic tests can precipitate the features of stress cardiomyopathy, a small observational series of patients shows.
  • Lab Assay Shows Promise in ARVC Diagnosis Hopes are that the test will sharpen diagnosis of the potentially lethal disorder in its early stages.
  • FDA Safety Changes: Arimidex, Coreg/Coreg CR, Myozyme The FDA has approved revisions to the safety labeling for anastrozole tablets (Arimidex), carvedilol tablets and extended-release tablets (Coreg, Coreg CR), and alglucosidase alfa injection (Myozyme).
  • Cardiomyopathies in South Asian Populations Associated With Deletion Population distribution of 25-bp deletion reflects the migratory history of Indian subcontinent.
  • IFNB-1b for CVC? A phase 2 trial has shown that interferon beta-1b–-a drug currently used to treat multiple sclerosis–-may be effective in chronic viral cardiomyopathy. But a phase 3 trial is needed for definitive proof of concept, say the study investigators and discussant.
  • Future Assays for Earlier MI Diagnosis Serial blood samples in patients with deliberately induced MIs (actually, they were the normal result of alcohol septal ablation therapy for hypertrophic obstructive cardiomyopathy) showed elevations in several molecules that could, in theory, help identify ongoing infarction as soon as 10 minutes after onset.
  • Immunosuppression and Virus-Negative Inflammatory Cardiomyopathy The findings support a strategy of first testing patients for persistent viral load before choosing a treatment strategy.
  • Half of Child CM Is Genetic About half of all children presenting with hypertrophic cardiomyopathy have mutations in exactly the same gene as is seen in adults with the condition, a new study has found. Unexplained hypertrophy in childhood should thus prompt genetic evaluation and analysis of all first-degree relatives where possible, say the researchers.
  • Hypolipidemic Drug Effective for Adult Myopathic CPT2 Deficiency Bezafibrate is the first therapy to relieve muscle pain and improve quality of life for patients with a mitochondrial fatty acid oxidation disorder.
  • Causes of Pregnancy-Related Deaths Elucidated Pregnancy-related deaths are usually the result of peripartum cardiomyopathy, preeclampsia, HELLP syndrome, fatty liver of pregnancy, and amniotic fluid emboli, according to a retrospective autopsy case analysis.
  • Recent vs Remote Cardiomyopathy Diagnosis: A DEFINITE Substudy CMS expanded its ICD coverage to include nonischemic patients, but only those with a diagnosis of > 9 months. However, results from a DEFINITE substudy challenge this CMS timeframe.
  • Influence of Etiology on Response to CRT Etiology of heart failure does not affect response to CRT and should not be used to optimize candidates for therapy.
  • DEFINITE Trial Shows Significant Mortality Benefit of ICDs Compared with standard medical therapy alone, ICDs plus standard therapy significantly reduced the incidence of arrhythmic death and showed a strong trend toward a reduction in all-cause mortality.
  • Is Nonsustained Ventricular Tachycardia a Risk Marker in HCM? According to the authors, NSVT is associated with a substantial increase in sudden death in young HCM patients, but there is no association between duration, frequency, and rate of NSVT episodes.
  • Is There a DEFINITE Role for ICDs in NICM Patients? Use of ICDs in nonischemic cardiomyopathy patients significantly reduces arrhythmic death and shows favorable trend toward reducing all-cause mortality; results considered "meaningfully significant."
  • MTWA Demonstrate Efficacy as Predictor of Events in DCM Patients Results of a prospective observational study suggest that MTWA observed on ECG during exercise testing is a potent predictor of ventricular tachyarrhythmic events in patients with idiopathic DCM.
  • ICDs vs Amiodarone: Results of the AMIOVIRT Trial Amiodarone therapy costs less and produces similar outcomes in patients with NIDCM and NSVT. Could it be a frontline prophylactic therapy? Results may not be ready for prime time, critics argue.
  • Sympathetic Nerve Sprouting Identified After Transplantation Transplanted hearts show evidence of sympathetic nerve sprouting and reinnervation - particularly around blood vessels - in postmortem studies. Nerve density highly variable from patient to patient.
 
 
 
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