Nature Clinical Practice Cardiovascular Medicine

• The Need to Test the Theories Behind the Polypill: Rationale Behind the Indian Polycap Study Cardiovascular polypill rationale in the setting of primary prevention is discussed as are drug combinations used in The Indian Polycap study.
  Nature Clinical Practice Cardiovascular Medicine, February 2009
• Hypertrophic Obstructive Cardiomyopathy and Sleep-Disordered Breathing: An Under-Recognized and Unfavorable Association Could obstructive sleep apnea be the reason cardiomyopathy symptoms remain for some patients, despite medical therapy?
  Nature Clinical Practice Cardiovascular Medicine, January 2009
• The Relevance of Prosthesis-patient Mismatch After Aortic Valve Replacement Patient-prosthesis mismatch after aortic valve replacement is associated with a high rate of events and increased mortality. The authors highlight the importance of identifying susceptible patients.
  Nature Clinical Practice Cardiovascular Medicine, December 2008
• Public Access Defibrillation: Advances From Japan New strategies that are increasing the use of automatic external defibrillators in Japan are presented. Learn more about these innovative initiatives.
  Nature Clinical Practice Cardiovascular Medicine, November 2008
• Play an ADAGIO With a STRADIVARIUS: The Right Patient for CB1 Receptor Antagonists? Results of the STRADIVARIUS and ADAGIO-Lipids trials have fueled debate about the use of the CB1 receptor antagonist rimonabant. Learn more here.
  Nature Clinical Practice Cardiovascular Medicine, October 2008
• Mechanisms of Disease: The Evolving Role of Regulatory T Cells in Atherosclerosis The role of regulatory T cells in atherosclerosis development is examined in this review article. Future therapies designed to attenuate atheroscelerosis through this mechanism may be forthcoming.
  Nature Clinical Practice Cardiovascular Medicine, September 2008
• The Use of High-Sensitivity Assays for C-reactive Protein in Clinical Practice The relevance of hsCRP testing in the primary and secondary prevention settings are reviewed. What do the data say and do they support proposed guidelines for clinical use of hsCRP tests?
  Nature Clinical Practice Cardiovascular Medicine, August 2008
• Inhibition of Microsomal Triglyceride Transfer Protein Alone or With Ezetimibe in Patients With Moderate Hypercholesterolemia Can microsomal triglyceride transfer protein (MTP) inhibitors provide an alternative way to lower LDL-cholesterol levels in patients who do not tolerate statins?
  Nature Clinical Practice Cardiovascular Medicine, August 2008
• Evaluation of a Screening Protocol Using Auscultation and Portable Echocardiography to Detect Asymptomatic Rheumatic Heart Disease in Tongan Schoolchildren What are the most appropriate screening strategies for asymptomatic rheumatic heart disease in developing countries?
  Nature Clinical Practice Cardiovascular Medicine, July 2008
• Relationships Between Leptin and C-reactive protein With Cardiovascular Disease in the Adult General Population The interactions between leptin and CRP, and their association with CVD, remain unclear. Could increased concentrations of both leptin and CRP confer a higher risk for CVD?
  Nature Clinical Practice Cardiovascular Medicine, July 2008
• Papillary Fibroelastoma of the Aortic Valve and Coronary Artery Disease Visualized by 64-slice CT Papillary fibroelastoma of the aortic valve is rare and may not cause symptoms, but does require treatment. Here is an account of how the problem was detected and treated in a 75-year-old male.
  Nature Clinical Practice Cardiovascular Medicine, June 2008
• Screening, Stem Cells, Biomarkers and Hypercholesterolemia: Our First Original Clinical Research NCP Cardiovascular Medicine has launched a clinical research section. The first accepted paper topics include population screening for rheumatic heart disease and a translational stem cell study.
  Nature Clinical Practice Cardiovascular Medicine, May 2008
• A Case of Cardiac Sarcoidosis Concealed by Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy A definitive diagnosis of cardiac sarcoidosis relies on the results of endomyocardial biopsy. In this Case Study the authors describe a patient whose biopsy was falsely negative for sarcoidosis.
  Nature Clinical Practice Cardiovascular Medicine, April 2008
• Tubercular Myocarditis Presenting With Ventricular Tachycardia Myocardial involvement is a rare complication of tuberculosis. Here, Khurana et al. report a case involving a 30-year-old man who presented with ventricular tachycardia.
  Nature Clinical Practice Cardiovascular Medicine, March 2008
• A Case of Vagally Mediated Idiopathic Ventricular Fibrillation A 25-year-old woman experienced three episodes of syncope over the course of 2 years. The attacks all occurred just after she sat down, and two were accompanied by convulsions. How can she be helped?
  Nature Clinical Practice Cardiovascular Medicine, February 2008
• Pheochromocytoma: Cyclic Attacks of Hypertension Alternating With Hypotension In this unusual case of catecholamine-producing tumors, what pharmacologic and surgical methods are employed to successfully treat the patient?
  Nature Clinical Practice Cardiovascular Medicine, January 2008
• Stress (Takotsubo) Cardiomyopathy -- A Novel Pathophysiological Hypothesis to Explain Catecholamine-induced Acute Myocardial Stunning Stress cardiomyopathy is reviewed and the authors suggest a novel pathophysiological explanation that focuses on the direct effects of high epinephrine levels on the ventricular myocardium.
  Nature Clinical Practice Cardiovascular Medicine, December 2007
• Acute Myocardial Infarction Caused by Spontaneous Postpartum Coronary Artery Dissection Here, the case of a patient who presented with an acute myocardial infarction five weeks after giving birth, and the steps taken to ensure her recovery.
  Nature Clinical Practice Cardiovascular Medicine, December 2007
• Technology Insight: Magnetic Resonance Angiography for the Evaluation of Patients With Peripheral Artery Disease Magnetic resonance imaging has emerged as an excellent means to diagnose peripheral arterial disease. The current article compares magnetic resonance imaging with other imaging modalities and reviews practical concerns with the practice of magnetic resonance angiography.
  Nature Clinical Practice Cardiovascular Medicine, November 2007
• Cardiac Fabry's Disease: An Unusual Cause of Left Ventricular Hypertrophy Here, the unusual case of a cardiac variant of Fabry's disease--a rare disorder characterized by a deficiency in the enzyme [alpha]-galactosidase A. What can be done for this patient?
  Nature Clinical Practice Cardiovascular Medicine, November 2007