Hematology-Oncology Ask The Experts Index

 
 
  • Follow-up Therapy for Locally Advanced Pancoast Tumor? A right-sided Pancoast tumor involving the upper lobe with rib destruction in a 54-year-old man remained unchanged after 4 cycles of carboplatin and paclitaxel and irradiation. What you would suggest?
  • Therapeutic Options for an Elderly Woman With Metastatic Non-Small-Cell Lung Cancer? PET scan of a 74-year-old woman who smokes revealed a tumor in the right lower lobe and 3 tumors near the adrenals. Biopsy confirmed squamous cell carcinoma. How would you proceed?
  • Use of Whole Fresh Blood for Transfusions Are there any indications for the use of whole fresh blood in today's transfusion practice?
  • Follow-up Therapy for Poorly Differentiated Breast Carcinoma? A 55-year-old, postmenopausal woman underwent lumpectomy in the right breast. Sixteen lymph nodes were clear of metastasis, ER and PR were highly positive, and HER-2/neu was negative. What to do?
  • Adjuvant Therapy for Receptor-Positive Multifocal Breast Cancer? A premenopausal 42-year-old woman has 3 separate foci of infiltrating grade 2, ER+, PR+, ductal carcinoma in the left breast following mastectomy. What would you suggest for adjuvant therapy?
  • A Boy Presents With Immune Thrombocytopenia Purpura for the Second Time If a 12-year-old boy presents for the second time with ITP, should he be labeled as a chronic ITP patient?
  • Management of Large Hyperplastic Gastric Polyps? What is the recommended approach to management of large (> 1-2 cm), hyperplastic gastric polyps usually in the antrum/lower body? Michael L. Kochman, MD, FACP, discusses this clinical scenario.
  • Albumin for Hypoalbuminemia in the Elderly Is it justifiable to administer 100 mL of 25% human albumin over 8-10 hours to a 70-year-old patient with hypoalbuminemia?
  • Treatment Options for Primary Cutaneous Lymphoma? A 76-year-old woman presented with erythematous cutaneous nodules over the scapula. Biopsy confirmed a diagnosis of large B-cell lymphoma. CT scans show no other disease. What would you recommend?
  • Diagnosis of Primary CNS Lymphoma Primary CNS lymphoma is the most common CNS neoplasm in HIV infection. Read this expert's advice on how to confirm a diagnosis.
  • Adjuvant Treatment for a Stage T1 Parotid Mucoepidermoid Carcinoma? A 50-year-old man underwent parotidectomy after diagnosis of a 1-cm, low-grade mucoepidermoid carcinoma. There was no adenopathy and surgical margins were clear. Is there a role for adjuvant therapy?
  • Metastatic Papillary Adenocarcinoma of Unknown Primary? CA-125 in a 66-year-old woman with a 5-cm lytic lesion in the right sacrum and a 4-cm pelvic mass fell from 224 and to 36 after chemoradiotherapy. What would you suggest at this point?
  • Minimizing Menopausal Symptoms From Endocrine Therapy? A 44-year-old woman with an ER+, PR+, node-positive breast cancer was started on tamoxifen and goserelin, but the menopausal symptoms were too difficult to bear. What would you recommend?
  • Follow-up Therapy for a Young Woman With T3Nx Breast Cancer? Core biopsy of a 7-cm lesion in a 37-year-old woman showed an infiltrating ductal carcinoma. She received neoadjuvant AC and docetaxel; there is no palpable mass. What should be the next step?
  • Follow-up Surveillance for Localized Breast Tumor? A 48-year-old woman underwent mastectomy for an ER-positive, PR-positive, 2.5-cm tumor of the right breast with no nodal involvement, received 6 courses of FAC, and started tamoxifen. What's next?
  • Hormonal Treatment for Recurrent ER-Negative, PR-Positive Breast Cancer? A 62-year-old woman with a 4-cm lobular carcinoma received chemotherapy and 5 years of tamoxifen. A year later, a 1.8-cm, ER-, PR+ tumor was found in the contralateral breast. What would you do?
  • Treatment Options for Bronchioloalveolar Carcinoma? A 55-year-old female former smoker was diagnosed with bronchioloalveolar cell carcinoma, possibly involving both lungs. No other metastases were noted, and her PS is 1. What would you suggest?
  • A 54-Year-Old Woman With Colon Polyps Michael L. Kochman, MD, FACP, discusses the possible next step in management and surveillance interval for this patient.
  • Local-Regional Advanced Tonsillar Carcinoma? A 44-year-old man with tonsillar carcinoma could not undergo resection because of rapid growth and skin involvement. He did not respond to a course of induction chemotherapy. What would you recommend?
  • Treatment for Borderline Ovarian Cancer? A young infertile patient with a unilateral ovarian cyst was diagnosed with a stage Ia papillary serous borderline adenocarcinoma. She conceived 1 month after oophorectomy. What would you suggest?
 
 
 
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