Faculty of 1000 Medicine

• Endocrine Treatment of Transsexual Persons: An Endocrine Society Clinical Practice Guideline...F1000 Ranking: "Changes Clinical Practice" The authors propose this practice guideline based upon a consensus process with the committees of different endocrine societies.
  Faculty of 1000 Medicine, November 2009
• Induction Of Labour Versus Expectant Monitoring For Gestational Hypertension or Mild Pre-Eclampsia After 36 Weeks' Gestation (HYPITAT). F1000 Ranking "Exceptional" and "Changes Practice" This multi-centric randomised clinical trial (RCT) gives us clear guidance on the management of term hypertension and can guide clinicians worldwide.
  Faculty of 1000 Medicine, October 2009
• Ocular Alterations In Patients of Alopecia Areata F1000 Ranking "Must Read" and "Changes Clinical Practice" Corticosteroid patches for Aalopecia areata (A) are significantly associated with cataracts and lens changes. All AA patients alopecia should have a rigorous ophthalmological examination before starting treatment.
  Faculty of 1000 Medicine, September 2009
• Childhood Risk Factors for Lifetime Anorexia Nervosa By Age 30 Years in a National Birth Cohort. F1000 Ranking "Changes Clinical Practice" This study is very important because it now identifies female sex, early feeding problems, and childhood under-eating as primary risk factors for the development of AN.
  Faculty of 1000 Medicine, September 2009
• Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer: F1000 Ranking "Changes Clinical Practice" The EGFR mutation is now testable on a large scale and treatable with gefitinib in patients with lung cancer.
  Faculty of 1000 Medicine, September 2009
• Quantification of the Survival Benefit Of Early Versus Deferred Cystectomy in High-Risk Non-Muscle Invasive Bladder Cancer (T1 G3) Ranked "Changes Clinical Practice" from F1000 The authors review the understaging and survival of patients who underwent early versus deferred radical cystectomy for high-risk non-muscle invasive bladder cancer
  Faculty of 1000 Medicine, September 2009
• Effect of Concomitant Pharmacotherapy on Electroconvulsive Therapy Outcomes: Short-Term Efficacy And Adverse Effects. Ranked "Changes Clinical Practice" from F1000 This RCT tested whether concomitant nortriptyline or venlafaxine enhances the efficacy of ECT.
  Faculty of 1000 Medicine, August 2009
• Prevalence and Repair of Intraoperatively Diagnosed Patent Foramen Ovale and Association With Perioperative Outcomes and Long-Term Survival: Ranked "Exceptional" from F1000 If a PFO is discovered during cardiac surgery, should it be repaired?
  Faculty of 1000 Medicine, August 2009
• Atorvastatin Reduces The Risk of Cardiovascular Events in Patients With Carotid Atherosclerosis...Ranked "Changes Clinical Practice" from F1000 Another statin hit -- this time it's a benefit for the carotid artery and stroke reduction.
  Faculty of 1000 Medicine, August 2009
• Locally Recurrent Prostate Cancer After Initial Radiation Therapy: A Comparison Of Salvage Radical Prostatectomy Versus Cryotherapy...Ranked "Changes Clinical Practice" from F1000 Go for the cure in some patients with recurrent prostate cancer and avoid the knee-jerk response of androgen therapy.
  Faculty of 1000 Medicine, August 2009
• Hyperlipidemia and Sexual Function in Premenopausal Women. Ranked "Changes Clinical Practice" from F1000 Could you help protect young adult women from future cardiovascular disease by asking about their sexual function?
  Faculty of 1000 Medicine, July 2009
• Public Health. Return of the Population Growth Factor. Ranked Must Read from F1000 Large families can lead to entrapment in poverty and poor health. Does this seem rather obvious? If so, why is it not more openly discussed?
  Faculty of 1000 Medicine, July 2009
• Effectiveness of Thigh-length Graduated Compression Stockings To Reduce the Risk of Deep Vein Thrombosis After Stroke (CLOTS trial 1): Ranked Exceptional from F1000 Should we now stop using compression stockings in acute stroke care?
  Faculty of 1000 Medicine, July 2009
• A Call for More Transparency of Registered Clinical Trials on Endometriosis. Ranked "Exceptional" by F1000 The need for exposure of important research in endometriosisto the medical and public eyes is long overdue.
  Faculty of 1000 Medicine, June 2009
• Long-Term Use of Antidepressants For Depressive Disorders and the Risk of Diabetes Mellitus. Ranked "Changes Clinical Practice" by F1000 Be sure to check glucose levels in patients who have been on antidepressants for long periods.
  Faculty of 1000 Medicine, June 2009
• Ultrasound-guided Regional Anesthesia and Analgesia: A Qualitative Systematic Review. Ranked "Must Read" by F1000 How useful is ultrasound guidance in reducing complications of regional anesthesia and analgesia?
  Faculty of 1000 Medicine, June 2009
• Coronary Bypass Surgery With Or Without Surgical Ventricular Reconstruction Ranked 9.6 from F1000 Does ventricular reconstruction improve mortality versus CABG alone? First results from STICH
  Faculty of 1000 Medicine, June 2009
• Prediction of Cure and Risk of Hypothyroidism in Patients Receiving 131I for Hyperthyroidism. Ranked "Changes Clinical Practice" by F1000 This significant article highlights, for the first time, that male patients with severe hyperthyroidism and those with a palpable goitre require larger doses of radioactive iodine.
  Faculty of 1000 Medicine, May 2009
• The Effect Of Postoperative Fasting On Vomiting In Children And Their Assessment Of Pain. A "Hidden Jewel" from F1000 Let them eat cake! Does feeding children who want to eat after an operation make them sicker?
  Faculty of 1000 Medicine, May 2009
• Clinical Update on the Pharmacology, Efficacy and Safety of Transdermal Buprenorphine. Ranked "Exceptional" by F1000 This old molecule is now available in a new transdermal preparation and may change the way chronic pain is managed.
  Faculty of 1000 Medicine, May 2009
• Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis. Ranked "Changes Clinical Practice" by F1000 Do statins benefit patients with CKD? This important study suggests an answer.
  Faculty of 1000 Medicine, May 2009
• Ovarian Conservation at the Time of Hysterectomy and Long-Term Health Outcomes in the Nurses' Health Study: Ranked "Changes Clinical Practice" by F1000 Women undergoing hysterectomy for benign disease prior to the age of 50 should be carefully counselled about the benefits and risks associated with concurrent prophylactic oophorectomy.
  Faculty of 1000 Medicine, May 2009
• Patient Preference as a Moderator of Outcome For Chronic Forms of Major Depressive Disorder Treated With Nefazodone, Cognitive Behavioral Analysis System of Psychotherapy, or Their Combination Ranked "Exceptional" by F1000, this study shows that patient preference between two equally effective treatments for depression, can have a dramatic impact on therapeutic outcome.
  Faculty of 1000 Medicine, April 2009
• Committee for Medicinal Products for Human Use (CHMP) Assessment on Efficacy of Antidepressants Ranked "Exceptional" by F1000m this paper from the European Medicines Agency (EMEA) justifies its past licensing of the newer antidepressants and maintains its position that they are useful.
  Faculty of 1000 Medicine, April 2009
• Does Breastfeeding Protect Against Substantiated Child Abuse And Neglect? Ranked "Hidden Jewel" by F1000 This elegant 15-year cohort study makes important connectipons between breast feeding and protection against abuse.
  Faculty of 1000 Medicine, April 2009