HIV/AIDS Ask The Experts Index

 
 
  • HAART Regimen for Lymphoma Patient With Renal Impairment? What regimen is best for an HIV-infected man with high viral load, renal impairment, normal liver and probable lymphoma?
  • Managing HIV-Related Cryptococcal Meningitis? How does one treat a patient whose CSF still grows C neoformans after 8 weeks of amphotericin plus flucytosine?
  • Interactions Between Heroin and Antiretrovirals? How are antiretroviral drugs most likely to be affected by concurrent heroin use?
  • Immunosuppression for HIV-Positive Kidney Transplant Recipient? What is the immunosuppressant regimen used by Starzl's group for HIV-positive transplant recipients?
  • Treating Gynecomastia in Patient on HAART? Besides surgery, could the management options include the use of tamoxifen?
  • Myasthenia Gravis in an HIV-Infected Woman? Please advise regarding her management. I am considering long-term prednisolone but will I then need to initiate HAART?
  • Risks of Other NNRTIs After Nevirapine-Induced Hepatotoxicity? If a patient developed severe hepatotoxicity from nevirapine, would there be any significant risk using another NNRTI?
  • Risk of Archived Resistance After Intrapartum Nevirapine? Will a woman who received single-dose intrapartum nevirapine 6 months ago respond to a nevirapine-based HAART regimen?
  • Likelihood of Resistance in Treatment-Experienced Patient? When resuming therapy after an interruption, can I assume he may still be drug-sensitive to previously used medications?
  • Reliability of Virtual Phenotype Resistance Assay? Is it premature to draw conclusions on the relative clinical utility of the virtual and actual phenotypes?
  • Neurologic Symptoms in HCV/HIV Coinfected Patient? A 26-year-old woman has hepatitis C virus (HCV) and was diagnosed with HIV infection 5 years ago. Her current plasma HIV-1 RNA level is < 50 copies/mL, and her CD4+ cell count is 1570 cells/mm3.
  • Treatment of Nelfinavir-Associated Diarrhea? I take care of a 7-year-old boy with HIV infection whose viral load is presently well controlled on a regimen of stavudine, lamivudine, efavirenz, and nelfinavir. He continues to have watery stools (usually 3-4/day) despite optimal treatment with loperamide and a negative work-up for other etiologies. Do you know of any other strategies that I could use to manage this problem? I do not want to lower the dose of nelfinavir as I am afraid of losing the excellent antiviral potency of the...
  • Treat Patient With Very Early HIV Infection? Are there clear benefits to initiating treatment for him now, and if so, for how long would you keep him on treatment? He does not have access to any research protocols.
  • Antiretroviral-Induced Xerostomia and Effects on Taste? One side effect of antiretroviral therapy is xerostomia. How should this be managed? Can antiretroviral agents cause changes in taste, particularly for sweetness? If so, how should this be managed?
  • Suppressed HIV Viral Load But Declining CD4+ Cell Count? Is there any indication to change antiretroviral therapy in a patient with viral load < 50 copies/mL for 4 years, but whose CD4+ cell count is progressively declining?
  • Recurrent Otitis Media in HIV-Infected Children? How long should I treat for mastoiditis? Do I have to treat until the TC image disappears? Should I maintain these children on gammaglobulin every 28 days or daily trimethoprim/sulfamethoxazole to try to lessen recurrent otitis? Do you use amoxicillin prophylaxis for recurrent otitis media? Do you think that I should change the antiretroviral regimen if the child is having recurrent otitis media with effusion, even if he has a good immunologic and virologic response?
  • Strategies to Reverse Fat Accumulation? Recently he noticed painless swelling in the neck region. On examination he has a buffalo hump and accumulation of fat below the chin and in the abdomen. His clinical diagnosis is clearly lipodystrophy.
  • Continue Antiretroviral Therapy Despite Multiclass Resistance? In the case of a highly treated HIV patient with advanced disease whose viral isolate is apparently resistant to all drugs commercially available, would you suggest continuing therapy, and particularly which drugs would you continue? Is there information on maintaining slower progression of illness with such continued treatment in the face of high-level resistance?
  • Managing Immune Reconstitution Hepatitis? Some say stop HAART, but couldn't this leave the patient resistant to several classes of HAART? Others say continue HAART and give steroids, which seems quite controversial.
  • Evidence-Based Treatment of HIV-2? Are there any evidence-based guidelines on the treatment of HIV-2? Which antiretroviral drugs are noneffective? Is the CD4+ cell count the only way to assess disease progression and response to therapy?
 
 
 
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