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The Travels of a Multidrug-Resistant Strain of HIV
Clinicians and patients remain highly interested in the concept of structured treatment interruption. One such approach involves patients cycling on and off ART for defined periods of time.
AIDS Clinical Care, May 2007
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Does HIV Infection Predispose to the Metabolic Syndrome?
Study of a large Midwestern cohort suggests that metabolic syndrome is no more common among the HIV-infected than among uninfected peers; lipid abnormalities were prominent in HIV-infected, however.
AIDS Clinical Care, April 2007
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Antiretroviral Therapy and Cardiovascular Disease
Dr. Paul Sax reviews the latest report from the DAD Study Group which suggests that long-term treatment with PI- but not NNRTI-based therapy slightly, but significantly, increased the risk for MI.
AIDS Clinical Care, April 2007
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Do HIV Testing Rates Improve When Written Consent Is No Longer Required?
Elimination of risk-based testing is part of the CDC's new HIV testing recommendations.
AIDS Clinical Care, March 2007
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Who Will Benefit from CCR5 Inhibitors?
Correlates of co-receptor tropism were investigated in a population of highly-treatment experienced patients.
AIDS Clinical Care, March 2007
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Long-Term CD4 Response: Where You Start Predicts Where You End Up
After 6 years of successful antiretroviral therapy for HIV, the only patients likely to achieve a low-to-normal CD4-cell count were those who had started treatment with CD4s >350.
AIDS Clinical Care, February 2007
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NNRTIs Best PIs ... Again
In a randomized trial of treatment-naive HIV patients, the most virologically active strategy was 2 NRTIs plus an NNRTI; a triple-class strategy yielded greater toxicity but not greater efficacy.
AIDS Clinical Care, February 2007
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After Virologic Rebound, Should T-20 Be Continued?
Continuing a failing antiretroviral regimen is usually not advised, but in some cases, even failing regimens continue to exert a modest anti-HIV effect. Is that true for T-20?
AIDS Clinical Care, February 2007
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High Lung Cancer Rates in AIDS Not Entirely Due to Smoking
Elevated lung cancer risk remains despite the advent of HAART. Young people are at a particularly elevated riskmore than 10-fold relative to HIV-negative people.
AIDS Clinical Care, February 2007
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HCV Clinical Practice: Few Referred for Treatment, Even Fewer Respond
In a large urban HIV clinic, fewer than 1% of coinfected individuals were successfully treated for HCV.
AIDS Clinical Care, December 2006
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Successful Antiretroviral Therapy Eliminates Virus from the CSF
New findings suggest that antiretroviral effects are magnified, not muffled, in the CNS.
AIDS Clinical Care, December 2006
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Intermittent HIV Treatment Fails Dramatically
The SMART study leaves little doubt that continuous antiretroviral therapy, for all its problems, is better for overall health than intermittent therapy.
AIDS Clinical Care, November 2006
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High Mortality in a South African XDR TB Outbreak
Researchers found alarmingly high prevalences of both multidrug-resistant and extensively drug-resistant TB among HIV-coinfected people in rural South Africa.
AIDS Clinical Care, November 2006
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Is Nonoccupational PEP Effective?
HIV seroconversion occurred in approximately 1% of adults who received PEP after nonoccupational exposure. Whether these seroconversions represent failures of PEP is unclear.
AIDS Clinical Care, November 2006
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CD4-Cell Decline Not Predicted by Viral Load
New findings suggest that baseline viral load, although very useful for assessing response to HIV therapy, should play a limited role in determining when to start treatment.
AIDS Clinical Care, October 2006
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CDC Recommends Universal, Routine HIV Screening for Adults
Revised recommendations call for integration of HIV testing into routine medical care.
AIDS Clinical Care, October 2006
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Liver-Related Deaths in HIV Patients
In a study conducted in resource-rich countries, about 15% of HIV patients died of liver-related causes, and these deaths were strongly associated with advanced immunodeficiency.
AIDS Clinical Care, October 2006
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Four Drugs Not Better Than Three for HIV
In HIV-infected patients starting antiretroviral therapy, addition of abacavir to zidovudine, lamivudine, and efavirenz does not improve treatment results.
AIDS Clinical Care, September 2006
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Rapid HIV Testing is Beginning to Make a Difference
Rapid tests could enable more HIV-infected people to know their serostatus and thus to receive early treatment and prevention services.
AIDS Clinical Care, August 2006
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Staccato Trial Supports CD4-Guided Treatment Interruption
However, these positive findings contrast with the negative results from two other CD4-guided TI trials presented at the 2006 Retrovirus Conference.
AIDS Clinical Care, August 2006
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Updated Guidelines for Treatment of STDs
Changes reflect increasing antibiotic resistance for some infections and new treatment options for others.
AIDS Clinical Care, August 2006
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One Pill, Once Daily: Now an Option for HIV Patients
The new (and long-awaited) tenofovir/FTC/efavirenz coformulation should be an effective option for treatment-naive patients, as well as for some treatment-experienced patients to reduce pill burden.
AIDS Clinical Care, July 2006
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Modeling the Survival Benefits of HIV Treatment in the U.S.
HIV treatments saved about 3 million years of life from 1989 through 2003 -- or about 13 years per treated person.
AIDS Clinical Care, July 2006
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Genetic Screening to Reduce Abacavir Hypersensitivity Reactions
Screening for the HLA B5701 allele prior to initiation of abacavir therapy may help reduce the incidence of abacavir hypersensitivity reaction.
AIDS Clinical Care, June 2006
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Pravastatin Increased Subcutaneous Fat in HIV-Infected Men
Since a positive effect of statins on adipocytes is biologically plausible, researchers should conduct larger follow-up studies to confirm these results in more heterogeneous patient populations.
AIDS Clinical Care, June 2006
