AIDS Clinical Care

• When to Start ART: Two Major Cohort Studies Published While the studies may differ in when exactly to begin treatment in asysmptomatic HIV patients, both add to a substantial body of evidence showing that untreated HIV infection has negative consequences.
  AIDS Clinical Care, April 2009
• Has HIV Become More Virulent? Some studies have suggested that as the HIV epidemic progresses, infected patients are presenting at progressively lower CD4-cell counts, perhaps reflecting an increase in the virulence of the virus.
  AIDS Clinical Care, April 2009
• More Support for Starting ART Earlier While the studies may differ in when exactly to begin treatment in asysmptomatic HIV patients, both add to a substantial body of evidence showing that untreated HIV infection has negative consequences.
  AIDS Clinical Care, April 2009
• Too Few HIV-Infected Patients Are Receiving Care Only 35% of HIV-infected adults in South Carolina received consistent HIV care from 2004 through 2006.
  AIDS Clinical Care, April 2009
• Too Few HIV-Infected Patients Are Receiving Care Only 35% of HIV-infected adults in South Carolina received consistent HIV care from 2004 through 2006.
  AIDS Clinical Care, March 2009
• More Support for Starting ART Earlier The findings in this report support early initiation of ART, before irreparable damage to the immune system occurs.
  AIDS Clinical Care, March 2009
• Pneumonia Risk Still Elevated in HIV Patients In a population-based study, the incidence of pneumonia was substantially increased in HIV-infected individuals, even those who were receiving ART and had near-normal CD4-cell counts.
  AIDS Clinical Care, November 2008
• Virologic Failure: The Risk of Delaying a Regimen Change Does the continuation a failing NNRTI-based regimen have significant clinical consequences?
  AIDS Clinical Care, November 2008
• CD4-Cell Counts and Non-AIDS-Defining Cancers: Data From the DAD Study The rate of fatal non-AIDS-defining cancers was 10 times lower in patients with CD4 counts >500 cells/mm3 than in those with CD4 counts <50 cells/mm3.
  AIDS Clinical Care, October 2008
• The Evolution of HIV Tropism in Individual Patients Among HIV-infected men in the MACS cohort, CXCR4-using virus emerged well before the CD3+ inflection point and the development of late-stage HIV disease.
  AIDS Clinical Care, October 2008
• SMART Study: Abacavir Use Associated with Increased Risk for CVD Patients who were receiving abacavir at study entry had elevated baseline levels of some inflammatory biomarkers. During the study, was abacavir use associated with higher rates of CVD risk?
  AIDS Clinical Care, September 2008
• Rapid HIV Testing in Emergency Departments - Beware of False Positives We need better ways to confirm or rule out the presence of HIV infection in patients whose rapid tests are reactive. Was this testing program a success?
  AIDS Clinical Care, September 2008
• Expanding the Options for Treatment-Naive HIV-Infected Patients: The ARTEMIS Study Learn why Darunavir will be a welcome addition to the current choices for initiating ART.
  AIDS Clinical Care, August 2008
• Life Expectancy Continues to Improve for HIV-Infected Patients ART Cohort Collaboration researchers provide updated estimates of survival for HIV-infected patients.
  AIDS Clinical Care, August 2008
• No Effect of Atazanavir or Lopinavir/r on Endothelial Function or Insulin Sensitivity Unlike indinavir, atazanavir and lopinavir/ritonavir do not induce endothelial dysfunction or change insulin sensitivity in healthy, HIV-negative men.
  AIDS Clinical Care, July 2008
• Beware Rapid HIV Testing in Late-Stage AIDS When clinical signs point to HIV infection, do not be deterred by a negative rapid test.
  AIDS Clinical Care, July 2008
• Delayed Initiation of HIV Care The initiation of HIV care is most timely when testing occurred at medical facilities, with referrals from nonmedical sites.
  AIDS Clinical Care, June 2008
• Enhancing Antiretroviral Activity in the Brain Can drugs with high CSF penetration treat HIV-associated neurological syndromes more effectively than others?
  AIDS Clinical Care, June 2008
• Rifampin and Lopinavir/r: A Combination to Avoid Learn why you should avoid the concomitant use of Rifampin and Lopinavir/r.
  AIDS Clinical Care, May 2008
• Abacavir and ddl Linked to Increased MI Risk Investigators from the DAD Study reported an unexpected association between recent use of abacavir or ddI and increased risk for myocardial infarction.
  AIDS Clinical Care, May 2008
• Low CD4-Cell Counts - Not Just About OI Risk Will maintaining high CD4-cell counts reduce the risk for AIDS-defining conditions, and also for non-AIDS-defining disease?
  AIDS Clinical Care, May 2008
• Both Fish Oil and Fibrates Reduce Triglyceride Levels Fish oil and fibrates have each been shown to reduce triglyceride levels in HIV-infected patients. However, few comparative data are available.
  AIDS Clinical Care, April 2008
• High Immune Activation in Patients With Undetectable Viral Loads and Low CD4-Cell Counts This article explores low CD4-cell counts among patients who control viral replication without antiretroviral therapy. Is immune activation a possible mechanism for this paradoxical response to HIV?
  AIDS Clinical Care, April 2008
• Does Raising Awareness of HIV Serostatus Lower HIV Incidence? Could an increased awareness of serostatus among people with HIV prevent a rise in the rate of new infections?
  AIDS Clinical Care, March 2008
• VA Study: ART Confers Negligible Risk for Heart Disease Are there any associations between longer durations of ART exposure and risk for heart disease in HIV-infected patients?
  AIDS Clinical Care, March 2008