HIV/AIDS News Index

 
 
  • CME Efavirenz May Be Best Initial Treatment of HIV-1 Infection Patients given efavirenz plus 2 nucleoside reverse transcriptase inhibitors were less likely to have virologic failure than those given lopinavir-ritonavir.
  • Anti-TNF Therapy "Viable Alternative" for Rheumatic Disease in HIV Patients HIV-positive individuals with rheumatic disease can be effectively treated with anti-tumor necrosis factor (TNF) agents, according to a report in the May issue of the Annals of the Rheumatic Diseases.
  • Universal Rapid HIV Testing During Labor Feasible in Developing Countries Rapid oral-fluid testing for HIV, counseling, and mother-to-child transmission (MTCT) prophylaxis in all women at the time of delivery are feasible and cost-effective in resource-poor settings, according to the results of a study from India.
  • Immunologic Recovery Seen After Chemotherapy for AIDS-Related NHL Patients who have undergone chemotherapy for AIDS-related non-Hodgkin's lymphoma (NHL) along with concomitant highly active antiretroviral therapy (HAART) do not experience prolonged suppression of immune function, according to UK researchers.
  • Free Antiretroviral Therapy Cuts Mortality in Malawi Since free antiretroviral therapy was offered to more than 80,000 HIV-infected adults in Malawi a few years ago, mortality has fallen by up to 35%, according to a report in the May 10th issue of The Lancet.
  • Rosuvastatin Interacts With Lopinavir and Ritonavir The results of a pharmacokinetic study in HIV-seronegative volunteers identified "unexpected and statistically significant" increases in rosuvastatin (Crestor) plasma concentrations when co-administered with the combination of lopinavir/ritonavir (Kaletra), a researcher involved in the study told Reuters Health.
  • Russia Must Grab Chance to Beat AIDS Epidemic: UN Russia will undo good progress in combating HIV/AIDS and miss the chance to stem the epidemic if it does not offer more help to people who inject themselves with drugs, U.N. AIDS chief Peter Piot said on Saturday.
  • Emtricitabine-Based Regimen Is Effective for Pediatric HIV Patients An emtricitabine-based antiretroviral regimen is safe and effective in pediatric patients infected with HIV, according to a report in the April issue of Pediatrics.
  • Lopinavir-Ritonavir Affects Pharmacokinetics of Irinotecan for Kaposi's Sarcoma In HIV patients with Kaposi's sarcoma, use of lopinavir-ritonavir has a substantial impact on the clearance of irinotecan (CPT11), Italian and US researchers report in the April issue of Clinical Pharmacology and Therapeutics.
  • Misdiagnoses Caused in Part by Overconfidence The rate of diagnostic error is as high as 15%; physician overconfidence and a lack of feedback after diagnosis are the most important contributors to the problem.
  • Adverse Effects With HIV Antiretroviral Therapy Initiation Differ by Race, Gender Among HIV-infected patients initiating antiretroviral therapy, there are significant differences in specific adverse events by gender and race but not in the overall rate of adverse events, death from any cause, or rates of toxicity-related treatment withdrawal, new research indicates.
  • Lopinavir Plus Rifampicin Feasible for Children With HIV and TB Antitubercular therapy with rifampicin for HIV-infected children receiving lopinavir, commonly used in combination antiretroviral treatment, results in a dramatic reduction in plasma concentrations of lopinavir.
  • Pneumocystis Often Accompanies Non-Pneumocystis Pneumonia in HIV Patients Pneumocystis colonization is common among hospitalized HIV infected patients with non-Pneumocystis pneumonia, researchers report in the April issue of Thorax.
  • CME/CE Review Addresses Strategies for Patient Adherence to Medications An updated review provides various methods of encouraging patients to adhere to their medications, but the reviewers say that there are significant limitations and that more research is needed.
  • Nearly Half of Initial Antiretroviral Regimens Don't Adhere to Guidelines A review of antiretroviral treatment (ART) regimens initiated in HIV-infected women revealed that nearly half of the regimens were either not specifically recommended for initial ART or were in fact against US HIV treatment guidelines.
  • Clinical Monitoring Suitable for HIV Drug Decisions in Resource-Limited Settings In resource-limited settings, clinical monitoring is virtually as good as viral load or CD4+ cell count measuring to determine whether HIV-infected patients need to switch from first-line therapy to another regimen, new research suggests.
  • MI Incidence Stable in Patients on HIV Antiretrovirals Although the cardiovascular risk profile has worsened in recent years for many patients on long-term combination antiretroviral therapy for HIV infection, there has not been a corresponding increase in myocardial infarctions and other cardiovascular events, researchers report in the April 1st issue of Clinical Infectious Diseases.
  • Genetics Influence Antiretroviral Therapy-Associated Lipoatrophy HIV-infected patients who possess a common mutation in the hemochromatosis gene (HFE), and possibly those who inherit mitochondrial DNA haplogroup J, may be protected from the development of lipoatrophy associated with antiretroviral therapy (ART), research suggests.
  • Tenofovir-Based HIV Postexposure Prophylaxis Promising Use of once-daily tenofovir DF along with lamivudine or emtricitabine may be more effective than previous regimens for non-occupational postexposure prophylaxis (NPEP) in people at high risk for HIV infection, investigators report in the April 1st issue of the Journal of Acquired Immune Deficiency Syndromes.
  • Gut-Associated Lymphoid Tissue a Source of Persistent HIV HIV persists in gut-associated lymphoid tissue (GALT) despite long-term treatment with antiretroviral drugs, according to a report in the March 1st issue of The Journal of Infectious Diseases.
 
 
 
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