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CME
Efavirenz May Be Best Initial Treatment of HIV-1 Infection
Patients given efavirenz plus 2 nucleoside reverse transcriptase inhibitors were less likely to have virologic failure than those given lopinavir-ritonavir.
Medscape Medical News, May 2008
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Anti-TNF Therapy "Viable Alternative" for Rheumatic Disease in HIV Patients
HIV-positive individuals with rheumatic disease can be effectively treated with anti-tumor necrosis factor (TNF) agents, according to a report in the May issue of the Annals of the Rheumatic Diseases.
Reuters Health Information, May 2008
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Universal Rapid HIV Testing During Labor Feasible in Developing Countries
Rapid oral-fluid testing for HIV, counseling, and mother-to-child transmission (MTCT) prophylaxis in all women at the time of delivery are feasible and cost-effective in resource-poor settings, according to the results of a study from India.
Reuters Health Information, May 2008
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Immunologic Recovery Seen After Chemotherapy for AIDS-Related NHL
Patients who have undergone chemotherapy for AIDS-related non-Hodgkin's lymphoma (NHL) along with concomitant highly active antiretroviral therapy (HAART) do not experience prolonged suppression of immune function, according to UK researchers.
Reuters Health Information, May 2008
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Free Antiretroviral Therapy Cuts Mortality in Malawi
Since free antiretroviral therapy was offered to more than 80,000 HIV-infected adults in Malawi a few years ago, mortality has fallen by up to 35%, according to a report in the May 10th issue of The Lancet.
Reuters Health Information, May 2008
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Rosuvastatin Interacts With Lopinavir and Ritonavir
The results of a pharmacokinetic study in HIV-seronegative volunteers identified "unexpected and statistically significant" increases in rosuvastatin (Crestor) plasma concentrations when co-administered with the combination of lopinavir/ritonavir (Kaletra), a researcher involved in the study told Reuters Health.
Reuters Health Information, May 2008
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Russia Must Grab Chance to Beat AIDS Epidemic: UN
Russia will undo good progress in combating HIV/AIDS and miss the chance to stem the epidemic if it does not offer more help to people who inject themselves with drugs, U.N. AIDS chief Peter Piot said on Saturday.
Reuters Health Information, May 2008
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Emtricitabine-Based Regimen Is Effective for Pediatric HIV Patients
An emtricitabine-based antiretroviral regimen is safe and effective in pediatric patients infected with HIV, according to a report in the April issue of Pediatrics.
Reuters Health Information, May 2008
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Lopinavir-Ritonavir Affects Pharmacokinetics of Irinotecan for Kaposi's Sarcoma
In HIV patients with Kaposi's sarcoma, use of lopinavir-ritonavir has a substantial impact on the clearance of irinotecan (CPT11), Italian and US researchers report in the April issue of Clinical Pharmacology and Therapeutics.
Reuters Health Information, May 2008
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Misdiagnoses Caused in Part by Overconfidence
The rate of diagnostic error is as high as 15%; physician overconfidence and a lack of feedback after diagnosis are the most important contributors to the problem.
WebMD Health News, April 2008
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Adverse Effects With HIV Antiretroviral Therapy Initiation Differ by Race, Gender
Among HIV-infected patients initiating antiretroviral therapy, there are significant differences in specific adverse events by gender and race but not in the overall rate of adverse events, death from any cause, or rates of toxicity-related treatment withdrawal, new research indicates.
Reuters Health Information, April 2008
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Lopinavir Plus Rifampicin Feasible for Children With HIV and TB
Antitubercular therapy with rifampicin for HIV-infected children receiving lopinavir, commonly used in combination antiretroviral treatment, results in a dramatic reduction in plasma concentrations of lopinavir.
Reuters Health Information, April 2008
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Pneumocystis Often Accompanies Non-Pneumocystis Pneumonia in HIV Patients
Pneumocystis colonization is common among hospitalized HIV infected patients with non-Pneumocystis pneumonia, researchers report in the April issue of Thorax.
Reuters Health Information, April 2008
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CME/CE
Review Addresses Strategies for Patient Adherence to Medications
An updated review provides various methods of encouraging patients to adhere to their medications, but the reviewers say that there are significant limitations and that more research is needed.
Medscape Medical News, April 2008
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Nearly Half of Initial Antiretroviral Regimens Don't Adhere to Guidelines
A review of antiretroviral treatment (ART) regimens initiated in HIV-infected women revealed that nearly half of the regimens were either not specifically recommended for initial ART or were in fact against US HIV treatment guidelines.
Reuters Health Information, April 2008
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Clinical Monitoring Suitable for HIV Drug Decisions in Resource-Limited Settings
In resource-limited settings, clinical monitoring is virtually as good as viral load or CD4+ cell count measuring to determine whether HIV-infected patients need to switch from first-line therapy to another regimen, new research suggests.
Reuters Health Information, April 2008
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MI Incidence Stable in Patients on HIV Antiretrovirals
Although the cardiovascular risk profile has worsened in recent years for many patients on long-term combination antiretroviral therapy for HIV infection, there has not been a corresponding increase in myocardial infarctions and other cardiovascular events, researchers report in the April 1st issue of Clinical Infectious Diseases.
Reuters Health Information, April 2008
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Genetics Influence Antiretroviral Therapy-Associated Lipoatrophy
HIV-infected patients who possess a common mutation in the hemochromatosis gene (HFE), and possibly those who inherit mitochondrial DNA haplogroup J, may be protected from the development of lipoatrophy associated with antiretroviral therapy (ART), research suggests.
Reuters Health Information, April 2008
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Tenofovir-Based HIV Postexposure Prophylaxis Promising
Use of once-daily tenofovir DF along with lamivudine or emtricitabine may be more effective than previous regimens for non-occupational postexposure prophylaxis (NPEP) in people at high risk for HIV infection, investigators report in the April 1st issue of the Journal of Acquired Immune Deficiency Syndromes.
Reuters Health Information, April 2008
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Gut-Associated Lymphoid Tissue a Source of Persistent HIV
HIV persists in gut-associated lymphoid tissue (GALT) despite long-term treatment with antiretroviral drugs, according to a report in the March 1st issue of The Journal of Infectious Diseases.
Reuters Health Information, April 2008