Therapeutic class: MACROLIDES  

Adult Min/Max Dose: 500.0mg/1500.0mg
Pediatric Min/Max Dose: 13.5mg/kg/16.5mg/kg

Common Dosages by Indication:

Acute Bacterial Maxillary Sinusitis	take 2 tablets (500 mg) by oral route every 12 hours take 2 tablets (500 mg) by oral route every 12 hours for 14 days take 1 tablet (500 mg) by oral route every 12 hours take 1 tablet (500 mg) by oral route every 12 hours for 14 days
Acute Exacerbation of Obstructive Chronic Bronchitis by M. Catarrhalis	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days
Acute Exacerbation of Obstructive Chronic Bronchitis by Streptococcus Pneumoniae	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days
Acute Exacerbation of Obstructive Chronic Bronchitis due to H. Flu	take 2 tablets (500 mg) by oral route every 12 hours take 2 tablets (500 mg) by oral route every 12 hours for 14 days take 2 tablets (500 mg) by oral route every 12 hours for 7 days take 1 tablet (500 mg) by oral route every 12 hours take 1 tablet (500 mg) by oral route every 12 hours for 14 days take 1 tablet (500 mg) by oral route every 12 hours for 7 days
Acute Maxillary Haemophilus Influenzae Sinusitis	take 2 tablets (500 mg) by oral route every 12 hours take 2 tablets (500 mg) by oral route every 12 hours for 14 days take 1 tablet (500 mg) by oral route every 12 hours take 1 tablet (500 mg) by oral route every 12 hours for 14 days
Acute Maxillary Moraxella Catarrhalis Sinusitis	take 2 tablets (500 mg) by oral route every 12 hours take 2 tablets (500 mg) by oral route every 12 hours for 14 days take 1 tablet (500 mg) by oral route every 12 hours take 1 tablet (500 mg) by oral route every 12 hours for 14 days
Acute Maxillary Streptococcus Pneumoniae Sinusitis	take 2 tablets (500 mg) by oral route every 12 hours take 2 tablets (500 mg) by oral route every 12 hours for 14 days take 1 tablet (500 mg) by oral route every 12 hours take 1 tablet (500 mg) by oral route every 12 hours for 14 days
Bacterial Pneumonia	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days
Chlamydial Pneumonia	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days
Chronic Bronchitis with Bacterial Exacerbation	take 2 tablets (500 mg) by oral route every 12 hours take 2 tablets (500 mg) by oral route every 12 hours for 14 days take 2 tablets (500 mg) by oral route every 12 hours for 7 days take 1 tablet (500 mg) by oral route every 12 hours take 1 tablet (500 mg) by oral route every 12 hours for 14 days take 1 tablet (500 mg) by oral route every 12 hours for 7 days
Disseminated Mycobacterium Avium Complex Infection	take 2 tablets (500 mg) by oral route 2 times per day take 2 tablets (500 mg) by oral route every 12 hours take 1 tablet (500 mg) by oral route 2 times per day take 1 tablet (500 mg) by oral route every 12 hours
Haemophilus Influenzae Bronchitis	take 2 tablets (500 mg) by oral route every 12 hours take 2 tablets (500 mg) by oral route every 12 hours for 14 days take 2 tablets (500 mg) by oral route every 12 hours for 7 days take 1 tablet (500 mg) by oral route every 12 hours take 1 tablet (500 mg) by oral route every 12 hours for 14 days take 1 tablet (500 mg) by oral route every 12 hours for 7 days
Haemophilus Influenzae Pneumonia	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days
Moraxella Catarrhalis Bronchitis	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days
Mycoplasmal Pneumonia	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days
Peptic Ulcer due to H. Pylori	take 2 tablets (500 mg) by oral route 2 times per day take 2 tablets (500 mg) by oral route 3 times per day take 2 tablets (500 mg) by oral route 2 times per day for 14 days take 2 tablets (500 mg) by oral route every 12 hours take 2 tablets (500 mg) by oral route every 12 hours for 14 days take 2 tablets (500 mg) by oral route 3 times per day for 14 days take 2 tablets (500 mg) by oral route every 8 hours for 14 days take 2 tablets (500 mg) by oral route every 8 hours take 1 tablet (500 mg) by oral route 2 times per day take 1 tablet (500 mg) by oral route 3 times per day take 1 tablet (500 mg) by oral route 2 times per day for 14 days take 1 tablet (500 mg) by oral route every 12 hours take 1 tablet (500 mg) by oral route every 12 hours for 14 days take 1 tablet (500 mg) by oral route every 8 hours take 1 tablet (500 mg) by oral route 3 times per day for 14 days take 1 tablet (500 mg) by oral route every 8 hours for 14 days
Pharyngitis due to Streptococcus Pyogenes	take 1 tablet (250 mg) by oral route every 12 hours for 10 days take 1 tablet (250 mg) by oral route every 12 hours
Pneumococcal Pneumonia	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days
Prevention of Mycobacterium Avium Complex Disease	take 2 tablets (500 mg) by oral route 2 times per day take 2 tablets (500 mg) by oral route every 12 hours take 1 tablet (500 mg) by oral route 2 times per day take 1 tablet (500 mg) by oral route every 12 hours
Skin and Skin Structure Infection	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days
Skin and Skin Structure Streptoccous Pyogenes Infection	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days
Staphylococcus Aureus Skin and Skin Structure Infection	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days
Streptococcal Pneumonia	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days
Streptococcal Tonsillitis	take 1 tablet (250 mg) by oral route every 12 hours for 10 days take 1 tablet (250 mg) by oral route every 12 hours
Streptococcus Pneumoniae Bronchitis	take 1 tablet (250 mg) by oral route every 12 hours take 1 tablet (250 mg) by oral route every 12 hours for 7 days take 1 tablet (250 mg) by oral route every 12 hours for 14 days

All Labeled Uses: Acute Bacterial Maxillary Sinusitis, Acute Exacerbation of Obstructive Chronic Bronchitis by M. Catarrhalis, Acute Exacerbation of Obstructive Chronic Bronchitis by Streptococcus Pneumoniae, Acute Exacerbation of Obstructive Chronic Bronchitis due to H. Flu, Acute Maxillary Haemophilus Influenzae Sinusitis, Acute Maxillary Moraxella Catarrhalis Sinusitis, Acute Maxillary Streptococcus Pneumoniae Sinusitis, Acute Otitis Media Infection, Bacterial Pneumonia, Bronchitis with Bacterial Exacerbations, Chlamydial Pneumonia, Chronic Bronchitis with Bacterial Exacerbation, Disseminated Mycobacterium Avium Complex Infection, Haemophilus Influenzae Acute Otitis Media, Haemophilus Influenzae Bronchitis, Haemophilus Influenzae Pneumonia, Lower Respiratory Infections, Moraxella Catarrhalis Acute Otitis Media, Moraxella Catarrhalis Bronchitis, Mycoplasmal Pneumonia, Peptic Ulcer due to H. Pylori, Pharyngitis due to Streptococcus Pyogenes, Pneumococcal Pneumonia, Prevention of Mycobacterium Avium Complex Disease, Skin and Skin Structure Infection, Skin and Skin Structure Streptoccous Pyogenes Infection, Staphylococcus Aureus Skin and Skin Structure Infection, Streptococcal Pneumonia, Streptococcal Tonsillitis, Streptococcus Acute Otitis Media, Streptococcus Pneumoniae Bronchitis, Upper Respiratory Infection
Unlabeled Uses: Boutonneuse Fever, Gastrointestinal Anthrax, Inhaled Anthrax, Legionnaires' Disease, Lyme Disease, Pertussis, Prevention of Bacterial Endocarditis

Contraindicated Drug Combination:
Clearly contraindicated in all cases and should not be dispensed or administered to the same patient:
QT PROLONGING AGENTS/TOREMIFENE - Additive side effects from both drugs
CLARITHROMYCIN; TELITHROMYCIN/DRONEDARONE - Increased effect of the latter drug
CLARITHROMYCIN; TROLEANDOMYCIN/TOLVAPTAN - Increased effect of the latter drug
CLARITHROMYCIN/SILODOSIN - Increased effect of the latter drug
CLARITHROMYCIN; TELITHROMYCIN/RANOLAZINE - Increased effect of the latter drug
CLARITHROMYCIN/CONIVAPTAN - Increased effect of the latter drug
QT PROLONGING AGENTS/DISOPYRAMIDE - Additive side effects from both drugs
QT PROLONGING AGENTS/AMIODARONE - Additive side effects from both drugs
CLARITHROMYCIN; TROLEANDOMYCIN/EPLERENONE - Increased effect of the latter drug
QT PROLONGING AGENTS/DROPERIDOL - Adverse reaction with both drugs
SELECTED MACROLIDE ANTIBIOTICS/ELETRIPTAN - Increased effect of the latter drug
QT PROLONGING AGENTS/LEVOMETHADYL - Adverse reaction with both drugs
QT PROLONGING AGENTS/SPARFLOXACIN - Adverse reaction with both drugs
QT PROLONGING AGENTS/HALOFANTRINE - Adverse reaction with both drugs
QT PROLONGING AGENTS/BEPRIDIL - Adverse reaction with both drugs
SELECTED MACROLIDE ANTIBIOTICS/PIMOZIDE - Adverse reaction of the latter drug
SELECTED MACROLIDE ANTIBIOTICS/ERGOTAMINE DERIVATIVES - Adverse reaction of the latter drug
ANTIBIOTICS/LIVE TYPHOID VACCINE - Decreased effect of the latter drug
SELECTED MACROLIDE ANTIBIOTICS/CISAPRIDE - Increased effect of the latter drug
MACROLIDE ANTIBIOTICS/ASTEMIZOLE; TERFENADINE - 

Severe Interaction:
Action is required to reduce the risk of severe adverse interaction.
SELECTED MACROLIDES/SELECTED HMG-COA REDUCTASE INHIBITORS - Adverse reaction of the latter drug
CLARITHROMYCIN; ERYTHROMYCIN/QUINUPRISTIN-DALFOPRISTIN - Adverse reaction of the former drug
QT PROLONGING AGENTS/ASENAPINE - 
QT PROLONGING AGENTS/TETRABENAZINE - 
QT PROLONGING AGENTS/NILOTINIB - 
CLARITHROMYCIN; TELITHROMYCIN/IXABEPILONE - 
ANTIBIOTICS/LIVE BCG VACCINE - Decreased effect of the latter drug
QT PROLONGING AGENTS/PALIPERIDONE - 
SLT MACROLIDES/SLT ANTINEOPLASTIC SYSTEMIC ENZYME INHIB - 
POSSIBLE QT PROLONGING AGENTS/ZIPRASIDONE - Additive side effects from both drugs
CLARITHROMYCIN; TROLEANDOMYCIN/FENTANYL - Increased effect of the latter drug
CLARITHROMYCIN; TELITHROMYCIN/COLCHICINE - Adverse reaction of the latter drug
QT PROLONGING AGENTS/MESORIDAZINE - 
QT PROLONGING AGENTS/THIORIDAZINE - 
SELECT MACROLIDES/SELECTED IMMUNOSUPPRESSANTS;TEMSIROLIMUS - 
MACROLIDE ANTIBIOTICS/DIGOXIN, ORAL - Increased effect of the latter drug
MACROLIDE ANTIBIOTICS/CARBAMAZEPINE - Increased effect of the latter drug
MACROLIDE ANTIBIOTICS/CYCLOSPORINE - Increased effect of the latter drug
SELECTED MACROLIDE ANTIBIOTICS/SELECTED ANTICOAGULANTS - Increased effect of the latter drug

Moderate Interaction:
Assess the risk to the patient and take action as needed.
CLARITHROMYCIN/SELECTED PROTEASE INHIBITORS - Adverse reaction of the former drug
CLARITHROMYCIN/NNRTI'S - Mixed effects of the former drug
CLARITHROMYCIN; TELITHROMYCIN/SAXAGLIPTIN - Increased effect of the latter drug
QT PROLONGING AGENTS/QUININE - Additive side effects from both drugs
CLARITHROMYCIN; TELITHROMYCIN/FESOTERODINE - Increased effect of the latter drug
CLARITHROMYCIN/ARIPIPRAZOLE - Increased effect of the latter drug
QT PROLONGING AGENTS/PALONOSETRON - Additive side effects from both drugs
CLARITHROMYCIN; TELITHROMYCIN/MARAVIROC - Increased effect of the latter drug
CLARITHROMYCIN/DARIFENACIN - Increased effect of the latter drug
QT PROLONGING AGENTS/LAPATINIB - Adverse reaction with both drugs
QT PROLONGING AGENTS/VORINOSTAT - Adverse reaction with both drugs
QT PROLONGING AGENTS/GADOXETATE - Adverse reaction with both drugs
QT PROLONGING AGENTS/POSACONAZOLE - Additive side effects from both drugs
QT PROLONGING AGENTS/LEVOFLOXACIN - Additive side effects from both drugs
SELECTED MACROLIDE ANTIBIOTICS/QUETIAPINE - Increased effect of the latter drug
QT PROLONGING AGENTS/HALOPERIDOL - Additive side effects from both drugs
QT PROLONGING AGENTS/NALIDIXIC ACID - Additive side effects from both drugs
QT PROLONGING AGENTS/NORFLOXACIN - Additive side effects from both drugs
QT PROLONGING AGENTS/GEMIFLOXACIN - Additive side effects from both drugs
QT PROLONGING AGENTS/FORMOTEROL - Additive side effects from both drugs
QT PROLONGING AGENTS/METHADONE - Additive side effects from both drugs
QT PROLONGING AGENTS/APOMORPHINE - Additive side effects from both drugs
QT PROLONGING AGENTS/PROPAFENONE - Additive side effects from both drugs
QT PROLONGING AGENTS/DOLASETRON - Additive side effects from both drugs
QT PROLONGING AGENTS/RISPERIDONE - Additive side effects from both drugs
QT PROLONGING AGENTS/SOTALOL - Additive side effects from both drugs
QT PROLONGING AGENTS/MOXIFLOXACIN - Additive side effects from both drugs
QT PROLONGING AGENTS/GATIFLOXACIN - Additive side effects from both drugs
QT PROLONGING AGENTS/DOFETILIDE - Additive side effects from both drugs
QT PROLONGING AGENTS/ARSENIC - Additive side effects from both drugs
CLARITHROMYCIN; TELITHROMYCIN/REPAGLINIDE - Increased effect of the latter drug
SELECTED MACROLIDES/ARTEMETHER; LUMEFANTRINE - Adverse reaction of the latter drug
SELECTED MACROLIDE ANTIBIOTICS/TOLTERODINE - Increased effect of the latter drug
MACROLIDE ANTIBIOTICS/BENZODIAZEPINES - Increased effect of the latter drug
CLARITHROMYCIN; ERYTHROMYCIN/SILDENAFIL; VARDENAFIL - Increased effect of the latter drug
SELECTED MACROLIDE ANTIBIOTICS/XANTHINE DERIVATIVES - Increased effect of the latter drug

Pediatric
Warning: SAFETY & EFFICACY NOT ESTABLISHED IN CHILDREN LESS THAN 6 MONTHS

Lactation
Precaution: MACROLIDES ARE EXCRETED IN BREASTMILK; INSUFF. DATA AVAIL. ON CLARITHROMYCIN

Pregnancy
Only When Necessary: NOT REC;ADV EFF OF PREG OUTCOME & FETAL DEVEL IN ANIMAL STUDIES 2-17 X HUM DOSE

Geriatric
Precaution: MAY REQUIRE DOSAGE ADJUSTMENT WITH SEVERE RENAL IMPAIRMENT

Less Frequent:
Abdominal Pain with Cramps, Diarrhea, Dysgeusia, Headache Disorder, Nausea, Vomiting

Rare:
Acute Hepatic Failure, Acute Pancreatitis, Anaphylaxis, Anxiety, Dental Discoloration, Hallucinations, Hypersensitivity Drug Reactions, Impaired Cognition, Insomnia, Interstitial Nephritis, Neuromuscular Blockade, Nightmares, Prolonged QT Interval, Pseudomembranous Enterocolitis, Psychotic Disorder, Skin Rash, Stevens-Johnson Syndrome, Thrombocytopenic Disorder, Tinnitus, Tonic Clonic Seizure, Torsades de Pointes, Toxic Epidermal Necrolysis, Ventricular Arrhythmias, Vertigo

Significant
Prolonged QT Interval, Pseudomembranous Enterocolitis, Severe Renal Disease, Torsades de Pointes, Ventricular Tachycardia

Possibly Significant
Myasthenia Gravis, Porphyria