Therapeutic class: CEPHALOSPORINS  

Adult Min/Max Dose: 750.0mg/4000.0mg
Pediatric Min/Max Dose: 20.0mg/kg/40.0mg/kg

Common Dosages by Indication:

Acute Otitis Media Infection	chew 1 tablet (250 mg) by oral route every 8 hours for 10 days chew 2 tablets (500 mg) by oral route every 8 hours for 10 days chew 1 tablet (250 mg) by oral route every 8 hours chew 2 tablets (500 mg) by oral route every 8 hours chew 1 tablet (375 mg) by oral route every 12 hours chew 1 tablet (375 mg) by oral route every 12 hours for 10 days
Haemophilus Influenzae Pneumonia	chew 1 tablet (250 mg) by oral route every 8 hours for 10 days chew 2 tablets (500 mg) by oral route every 8 hours for 10 days chew 1 tablet (250 mg) by oral route every 8 hours chew 2 tablets (500 mg) by oral route every 8 hours chew 1 tablet (375 mg) by oral route every 12 hours chew 1 tablet (375 mg) by oral route every 12 hours for 10 days
Lower Respiratory Infections	chew 1 tablet (250 mg) by oral route every 8 hours for 10 days chew 2 tablets (500 mg) by oral route every 8 hours for 10 days chew 1 tablet (250 mg) by oral route every 8 hours chew 2 tablets (500 mg) by oral route every 8 hours chew 1 tablet (375 mg) by oral route every 12 hours chew 1 tablet (375 mg) by oral route every 12 hours for 10 days
Pharyngitis	chew 1 tablet (250 mg) by oral route every 8 hours for 10 days chew 2 tablets (500 mg) by oral route every 8 hours for 10 days chew 1 tablet (250 mg) by oral route every 8 hours chew 2 tablets (500 mg) by oral route every 8 hours chew 1 tablet (375 mg) by oral route every 12 hours chew 1 tablet (375 mg) by oral route every 12 hours for 10 days
Pneumonia	chew 1 tablet (250 mg) by oral route every 8 hours for 10 days chew 2 tablets (500 mg) by oral route every 8 hours for 10 days chew 1 tablet (250 mg) by oral route every 8 hours chew 2 tablets (500 mg) by oral route every 8 hours chew 1 tablet (375 mg) by oral route every 12 hours chew 1 tablet (375 mg) by oral route every 12 hours for 10 days
Skin and Skin Structure Infection	chew 1 tablet (250 mg) by oral route every 8 hours for 10 days chew 2 tablets (500 mg) by oral route every 8 hours for 10 days chew 1 tablet (250 mg) by oral route every 8 hours chew 2 tablets (500 mg) by oral route every 8 hours chew 1 tablet (375 mg) by oral route every 12 hours chew 1 tablet (375 mg) by oral route every 12 hours for 10 days
Streptococcal Pneumonia	chew 1 tablet (250 mg) by oral route every 8 hours for 10 days chew 2 tablets (500 mg) by oral route every 8 hours for 10 days chew 1 tablet (250 mg) by oral route every 8 hours chew 2 tablets (500 mg) by oral route every 8 hours chew 1 tablet (375 mg) by oral route every 12 hours chew 1 tablet (375 mg) by oral route every 12 hours for 10 days
Tonsillitis	chew 1 tablet (250 mg) by oral route every 8 hours for 10 days chew 2 tablets (500 mg) by oral route every 8 hours for 10 days chew 1 tablet (250 mg) by oral route every 8 hours chew 2 tablets (500 mg) by oral route every 8 hours chew 1 tablet (375 mg) by oral route every 12 hours chew 1 tablet (375 mg) by oral route every 12 hours for 10 days
Upper Respiratory Infection	chew 1 tablet (250 mg) by oral route every 8 hours for 10 days chew 2 tablets (500 mg) by oral route every 8 hours for 10 days chew 1 tablet (250 mg) by oral route every 8 hours chew 2 tablets (500 mg) by oral route every 8 hours chew 1 tablet (375 mg) by oral route every 12 hours chew 1 tablet (375 mg) by oral route every 12 hours for 10 days
Urinary Tract Infections	chew 1 tablet (250 mg) by oral route every 8 hours for 10 days chew 2 tablets (500 mg) by oral route every 8 hours for 10 days chew 1 tablet (250 mg) by oral route every 8 hours chew 2 tablets (500 mg) by oral route every 8 hours chew 1 tablet (375 mg) by oral route every 12 hours chew 1 tablet (375 mg) by oral route every 12 hours for 10 days

All Labeled Uses: Acute Otitis Media Infection, Haemophilus Influenzae Pneumonia, Lower Respiratory Infections, Pharyngitis, Pneumonia, Skin and Skin Structure Infection, Streptococcal Pneumonia, Tonsillitis, Upper Respiratory Infection, Urinary Tract Infections
Unlabeled Uses: Pediatric Fever without a Source

Contraindicated Drug Combination:
Clearly contraindicated in all cases and should not be dispensed or administered to the same patient:
ANTIBIOTICS/LIVE TYPHOID VACCINE - Decreased effect of the latter drug

Severe Interaction:
Action is required to reduce the risk of severe adverse interaction.
ANTIBIOTICS/LIVE BCG VACCINE - Decreased effect of the latter drug

Moderate Interaction:
Assess the risk to the patient and take action as needed.
SELECTED CEPHALOSPORINS/PROBENECID - Adverse reaction of the former drug
SELECTED CEPHALOSPORINS/ALUMINUM AND MAGNESIUM COMPOUNDS - Decreased effect of the former drug
CEPHALOSPORINS/AMINOGLYCOSIDES - Increased effect of the latter drug

Pediatric
Warning: NO DOSING GUIDELINES AVAILABLE FOR NEONATES LESS THAN 1 MONTH.

Lactation
No Known Risk: OTHER CEPHALASPORINS COMPATIBLE PER AAP;OBSERVE FOR POSSIBLE DIARRHEA

Pregnancy
Possibly Safe

Geriatric
Precaution: ADJUST DOSAGE OR DOSE INTERVAL AS NEEDED

Most Frequent:
Serum Sickness, Vulvovaginal Candidiasis

Less Frequent:
Abdominal Pain with Cramps, Diarrhea, Nausea, Oral Candidiasis, Vomiting

Rare:
Allergic Reactions, Anaphylaxis, Angioedema, Drug Fever, Erythema, Erythema Multiforme, Hemolytic Anemia, Hypoprothrombinemia, Pruritus of Skin, Pseudomembranous Enterocolitis, Renal Disease, Seizure Disorder, Skin Rash, Stevens-Johnson Syndrome

Significant
Pseudomembranous Enterocolitis