Therapeutic class: ANGIOTENSIN II RECEPTOR ANTAGONISTS  

Adult Min/Max Dose: 4.0mg/32.0mg

Common Dosages by Indication:

Hypertension

take 1 tablet (4 mg) by oral route once daily take 2 tablets (8 mg) by oral route once daily take 1 tablet (4 mg) by oral route 2 times per day take 2 tablets (8 mg) by oral route 2 times per day take one-half tablet (2 mg) by oral route once daily take one-half tablet (2 mg) by oral route 2 times per day take 1 tablet (8 mg) by oral route 2 times per day take 1 tablet (8 mg) by oral route once daily take 2 tablets (16 mg) by oral route 2 times per day take 2 tablets (16 mg) by oral route once daily take 1 tablet (16 mg) by oral route 2 times per day take 1 tablet (16 mg) by oral route once daily take 2 tablets (32 mg) by oral route once daily take 1 tablet (32 mg) by oral route once daily

All Labeled Uses: Chronic Heart Failure, Hypertension
Unlabeled Uses: Diabetic Nephropathy, Diastolic Heart Failure, Nondiabetic Proteinuric Nephropathy, Prevention of Recurrent Atrial Fibrillation

Severe Interaction:
Action is required to reduce the risk of severe adverse interaction.
ACE INHIBITORS; ARB'S/LITHIUM - 
ACE INHIBITORS; ARBS/ORAL SODIUM PHOSPHATE - Adverse reaction of the latter drug

Moderate Interaction:
Assess the risk to the patient and take action as needed.
ACE INHIBITORS; ARB'S/SELECTED NSAIDS - Decreased effect of the former drug
ACE INHIBITORS; ARB'S/POTASSIUM SPARING DIURETICS - Adverse reaction with both drugs
ACE INHIBITORS; ARB'S/POTASSIUM PREPARATIONS - Adverse reaction with both drugs
ACE INHIBITORS; ARB'S/LOOP DIURETICS - Increased effect of the latter drug
ACE INHIBITORS; ARB'S/DROSPIRENONE - Additive side effects from both drugs

Pediatric
Warning: SAFETY & EFFICACY NOT ESTABLISHED FOR PTS LESS THAN 18 YEARS.

Lactation
Precaution: INSUFF HUMAN DATA; EXCRETED IN RATS

Pregnancy
Not Recommended: CAT D 2ND & 3RD TRIM.; STOP ASAP. ARBS ASSOC. W/FETAL MORBIDITY/MORTALITY.

Geriatric
Precaution: RENAL FAILURE AND HYPOTENSION MORE COMMON IN AGE>75

Less Frequent:
Back Pain, Dizziness, Headache Disorder, Pharyngitis, Rhinitis, Upper Respiratory Infection

Rare:
Abnormal Hepatic Function Tests, Agranulocytosis, Disease of Liver, Gout, Hepatitis, Hyperkalemia, Hyperuricemia, Hyponatremia, Hypotension, Leukopenia, Neutropenic Disorder, Pruritus of Skin, Renal Disease, Renal Failure, Rhabdomyolysis, Thrombocytopenic Disorder, Urticaria

Most Significant
Angioedema, Pregnancy

Significant
Hyperkalemia, Hypotension, Hypovolemia

Possibly Significant
Disease of Liver, Renal Artery Stenosis, Renal Disease with Mild to Moderate Renal Function Impairment, Surgical Procedure