Therapeutic class: ANTICONVULSANTS, MISCELLANEOUS  

Adult Min/Max Dose: 200.0mg/1600.0mg
Pediatric Min/Max Dose: 10.0mg/kg/35.0mg/kg

Common Dosages by Indication:

Complex-Partial Epilepsy	take 1 tablet (200 mg) by oral route every 8 hours take 2 tablets (400 mg) by oral route every 8 hours take 1 tablet (200 mg) by oral route every 6 hours take 2 tablets (400 mg) by oral route every 6 hours take 1 tablet (200 mg) by oral route every 12 hours take 2 tablets (400 mg) by oral route every 12 hours
Epilepsy	take 1 tablet (200 mg) by oral route every 8 hours take 2 tablets (400 mg) by oral route every 8 hours take 1 tablet (200 mg) by oral route every 6 hours take 2 tablets (400 mg) by oral route every 6 hours take 1 tablet (200 mg) by oral route every 12 hours take 2 tablets (400 mg) by oral route every 12 hours
Mixed Epilepsy	take 1 tablet (200 mg) by oral route every 8 hours take 2 tablets (400 mg) by oral route every 8 hours take 1 tablet (200 mg) by oral route every 6 hours take 2 tablets (400 mg) by oral route every 6 hours take 1 tablet (200 mg) by oral route every 12 hours take 2 tablets (400 mg) by oral route every 12 hours
Tonic-Clonic Epilepsy	take 1 tablet (200 mg) by oral route every 8 hours take 2 tablets (400 mg) by oral route every 8 hours take 1 tablet (200 mg) by oral route every 6 hours take 2 tablets (400 mg) by oral route every 6 hours take 1 tablet (200 mg) by oral route every 12 hours take 2 tablets (400 mg) by oral route every 12 hours
Trigeminal Neuralgia	take 1 tablet (200 mg) by oral route every 12 hours take 2 tablets (400 mg) by oral route every 12 hours

All Labeled Uses: Complex-Partial Epilepsy, Epilepsy, Mixed Epilepsy, Tonic-Clonic Epilepsy, Trigeminal Neuralgia
Unlabeled Uses: Attention-Deficit Hyperactivity Disorder, Bipolar Disorder in Remission, Diabetes Insipidus, Manic Bipolar Disorder, Mixed Bipolar I Disorder, Neuralgia, Paroxysmal Choreoathetosis, Prevention of Seizures following Cranial Trauma or Surgery, Restless Legs Syndrome

Contraindicated Drug Combination:
Clearly contraindicated in all cases and should not be dispensed or administered to the same patient:
CARBAMAZEPINE; OXCARBAZEPINE/MONOAMINE OXIDASE INHIBITORS - 
CARBAMAZEPINE; PHENOBARBITAL; PHENYTOIN/RANOLAZINE - Decreased effect of the latter drug
SELECTED ANTICONVULSANTS/NIMODIPINE - Decreased effect of the latter drug
CARBAMAZEPINE/VORICONAZOLE - Decreased effect of the latter drug
SELECTED ANTICONVULSANTS/DELAVIRDINE; ETRAVIRINE - Decreased effect of the latter drug
CARBAMAZEPINE/NEFAZODONE - Decreased effect of the latter drug

Severe Interaction:
Action is required to reduce the risk of severe adverse interaction.
CARBAMAZEPINE/MACROLIDE ANTIBIOTICS - Increased effect of the former drug
SELECTED ANTICONVULSANTS/TELITHROMYCIN - 
CARBAMAZEPINE/ISONIAZID - Adverse reaction of the latter drug
CARBAMAZEPINE; PHENOBARBITAL; PHENYTOIN/DRONEDARONE - 
CARBAMAZEPINE; PHENYTOIN; BARBITURATES/TOLVAPTAN - 
CARBAMAZEPINE; PHENOBARBITAL; PHENYTOIN/EVEROLIMUS - 
SELECTED ANTICONVULSANTS/FESOTERODINE - Decreased effect of the latter drug
SELECTED ANTICONVULSANTS/TEMSIROLIMUS - 
SELECTED ANTICONVULSANTS/IRINOTECAN - Decreased effect of the latter drug
SELECTED ANTICONVULSANTS/POSACONAZOLE - 
SLT ANTICONVUL/SLT ANTINEOPLASTIC SYSTEMIC ENZYME INHIB - 
SELECTED ANTICONVULSANTS/ERLOTINIB - 
TRICYCLIC COMPOUNDS; CARBAMAZEPINE/TRAMADOL - Adverse reaction with both drugs
CARBAMAZEPINE/PROTEASE INHIBITORS - Increased effect of the former drug
CARBAMAZEPINE; RUFINAMIDE/HORMONAL CONTRACEPTIVES - Decreased effect of the latter drug
CARBAMAZEPINE/THEOPHYLLINES - Adverse reaction with both drugs
CARBAMAZEPINE/CLOZAPINE - Decreased effect of the latter drug
CARBAMAZEPINE/PROPOXYPHENE - Increased effect of the former drug

Moderate Interaction:
Assess the risk to the patient and take action as needed.
CARBAMAZEPINE/DANAZOL - Increased effect of the former drug
CARBAMAZEPINE/SELECTED CALCIUM CHANNEL BLOCKERS - Increased effect of the former drug
CARBAMAZEPINE/CIMETIDINE - Increased effect of the former drug
CARBAMAZEPINE/SELECTED SSRI'S - Adverse reaction of the former drug
CARBAMAZEPINE/SELECTED AZOLE ANTIFUNGALS - Mixed effects of the former drug
CARBAMAZEPINE/SIMVASTATIN - Decreased effect of the latter drug
SELECTED ANTICONVULSANTS/MARAVIROC - Decreased effect of the latter drug
SELECTED ANTICONVULSANTS/LAMOTRIGINE - Decreased effect of the latter drug
SELECTED ANTICONVULSANTS/EXEMESTANE - Decreased effect of the latter drug
CARBAMAZEPINE/RISPERIDONE - Decreased effect of the latter drug
CARBAMAZEPINE/ARIPIPRAZOLE - Decreased effect of the latter drug
CARBAMAZEPINE/CASPOFUNGIN - Decreased effect of the latter drug
CARBAMAZEPINE/ANTICOAGULANTS - Decreased effect of the latter drug
CARBAMAZEPINE/CYCLOSPORINE - Decreased effect of the latter drug
CARBAMAZEPINE/FELBAMATE - Decreased effect of the former drug
CARBAMAZEPINE/VALPROIC ACID - Decreased effect of the latter drug
CARBAMAZEPINE/HALOPERIDOL - Decreased effect of the latter drug
CARBAMAZEPINE/LITHIUM - Increased effect of the latter drug
BARBITURATES; CARBAMAZEPINE/DOXYCYCLINE - Decreased effect of the latter drug

Pediatric
Warning: NO LONG-TERM SAFETY DATA;CAUTION IN MIXED SEIZURE DISORD W/ATYP ABSENCE SEIZR

Lactation
No Known Risk: AMERICAN ACAD OF PEDIATRICS(AAP) CONSIDERS DRUG COMPATIBLE WITH BREASTFEEDING

Pregnancy
Not Recommended: TERATOGENIC; CONSULT MD-ORAL VIT K MAY LOWER NEONATE RISK FROM VIT K DEFICIENCY

Geriatric
Precaution: POSSIBLE CONFUSION/AGITATION, A/V BLOCK, BRADYCARDIA, OR SIADH

Most Frequent:
Ataxia, Blurred Vision, Diplopia, Dizziness, Drowsy, Impaired Cognition, Nausea, Nystagmus, Vomiting

Less Frequent:
Allergic Dermatitis, Allergic Reactions, Behavioral Disorders, Hyponatremia, Lupus-Like Syndrome, Severe Diarrhea, SIADH Syndrome, Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis

Rare:
Abdominal Pain with Cramps, Acute Intermittent Porphyria, Agranulocytosis, Alopecia, Anorexia, Aplastic Anemia, Arthralgia, Atrioventricular Block, Blood Dyscrasias, Bone Marrow Depression, Bradycardia, Chronic Heart Failure, Conduction Disorder of the Heart, Constipation, Cramps, Cramps in Legs, Depression, Diarrhea, Edema, Eosinophilia, Erectile Dysfunction, Fainting, Fatigue, General Weakness, Glossitis, Headache Disorder, Hepatitis, Hyperhidrosis, Hypocalcemia, Hypotension, Leukopenia, Lymphadenopathy, Myalgia, Nervousness, Pancytopenia, Paresthesia, Peripheral Neuropathy, Renal Disease, Renal Failure, Skin Photosensitivity, Slurred Speech, Stomatitis, Suicidal Ideation, Thrombocytopenic Disorder, Thrombophlebitis, Tremors, Xerostomia

Most Significant
Bone Marrow Depression, Carbamazepine Toxicity, Complete Atrioventricular Block, Pregnancy

Significant
Acute Intermittent Porphyria, Agranulocytosis, Aplastic Anemia, HLA-B 1502 Positive Status, Suicidal Ideation, Thrombocytopenic Disorder

Possibly Significant
Absence Epilepsy, Chronic Heart Failure, Conduction Disorder of the Heart, Coronary Artery Disease, Depression, Disease of Liver, Glaucoma, Hypercholesterolemia, Hypertension, Hyponatremia, Mood Changes, Ocular Hypertension, Renal Disease, SIADH Syndrome, Urinary Retention