Therapeutic class: NONSTEROIDAL ANTI-INFLAMMATORY AGENTS  

Adult Min/Max Dose: 50.0mg/150.0mg
Pediatric Min/Max Dose: 0.3mg/kg/3.0mg/kg

Common Dosages by Indication:

Ankylosing Spondylitis	take 1 tablet (50 mg) by oral route 2 times per day
Dysmenorrhea	take 1 tablet (50 mg) by oral route 3 times per day
Osteoarthritis	take 1 tablet (50 mg) by oral route 2 times per day take 1 tablet (50 mg) by oral route 3 times per day
Pain	take 1 tablet (50 mg) by oral route 3 times per day
Rheumatoid Arthritis	take 1 tablet (50 mg) by oral route 2 times per day take 1 tablet (50 mg) by oral route 3 times per day take 1 tablet (50 mg) by oral route 4 times per day

All Labeled Uses: Ankylosing Spondylitis, Dysmenorrhea, Osteoarthritis, Pain, Rheumatoid Arthritis
Unlabeled Uses: Bursitis, Renal Colic, Tendonitis

Contraindicated Drug Combination:
Clearly contraindicated in all cases and should not be dispensed or administered to the same patient:
SELECTED NEPHROTOXIC AGENTS/CIDOFOVIR - Adverse reaction with both drugs
NSAID;ASPIRIN/KETOROLAC - Adverse reaction with both drugs

Severe Interaction:
Action is required to reduce the risk of severe adverse interaction.
NSAID'S/ORAL SODIUM PHOSPHATE - Adverse reaction of the latter drug
SELECTED NSAIDS; ASPIRIN/PEMETREXED - Increased effect of the latter drug
NSAIDS/METHOTREXATE - Increased effect of the latter drug

Moderate Interaction:
Assess the risk to the patient and take action as needed.
NSAIDS/LITHIUM - Increased effect of the latter drug
SELECTED NSAIDS/PROBENECID - Increased effect of the former drug
NSAIDS/ERLOTINIB - Adverse reaction of the latter drug
NSAIDS/TENOFOVIR - Additive side effects from both drugs
NSAIDS/DROSPIRENONE - Additive side effects from both drugs
NSAIDS; ASPIRIN/SSRI'S; SNRI'S - Adverse reaction with both drugs
NSAIDS/SELECTED PLATELET AGGREGATION INHIBITORS - Additive side effects from both drugs
NSAIDS/HEPARINS - Additive side effects from both drugs
NSAIDS/ANTICOAGULANTS - Increased effect of the latter drug
NSAIDS/CYCLOSPORINE - Adverse reaction with both drugs
SELECTED NSAIDS/TRIAMTERENE; AMILORIDE - Adverse reaction of the latter drug
SELECTED NSAIDS/ACE INHIBITORS; ARB'S - Decreased effect of the latter drug

Pediatric
Warning: SAFETY AND EFFICACY IN PEDIATRICS HAVE NOT BEEN ESTABLISHED.

Lactation
Precaution: USE NOT RECOMMENDED, MAY CAUSE ADVERSE EFFECT.

Pregnancy
FDB Contraindicated or Not Recommended: FDA CAT C. NOT RECOM,RISK OF PREMATURE CLOSURE OF DUCT ARTERIOSUS,MISCARRIAGE

Geriatric
Precaution: (SOM)(BEERS02)RISK OF SERIOUS/FATAL GI BLEED,ULCER; CV/RENAL ADV.EFX

Most Frequent:
Abdominal Pain with Cramps, Body Fluid Retention, Constipation, Diarrhea, Edema, Gastric Hypersecretory Conditions, Headache Disorder, Nausea

Less Frequent:
Abdominal Swelling, Angina, Conduction Disorder of the Heart, Dizziness, Esophageal Ulcer, Flatulence, Gastric Ulcer, Gastrointestinal Ulcer, Peptic Ulcer, Pruritus of Skin, Skin Rash, Tinnitus

Rare:
Abnormal Hepatic Function Tests, Acute Pancreatitis, Agranulocytosis, Allergic Dermatitis, Allergic Reactions, Anaphylaxis, Anemia, Angioedema, Anorexia, Aphthous Stomatitis, Aplastic Anemia, Bloody Stools, Bloody Vomit, Blurred Vision, Bronchospastic Pulmonary Disease, Bruising, Bullous Dermatitis, Cerebrovascular Accident, Chest Pain, Chest Tightness, Chronic Heart Failure, Colitis, Cystitis, Depression, Diplopia, Drowsy, Drug-Induced Hepatitis, Dysgeusia, Dyspnea, Ecchymosis, Epistaxis, Erythema Multiforme, Exfoliative Dermatitis, Fatigue, Flushing, Gastrointestinal Hemorrhage, Gastrointestinal Perforation, Hearing Disorder, Hematuria, Hemolytic Anemia, Hepatitis, Hyperhidrosis, Hypertension, Increased Urinary Frequency, Insomnia, Interstitial Nephritis, Irritability, Jaundice, Laryngeal Edema, Leukopenia, Memory Impairment, Mental Impairment, Metrorrhagia, Mood Changes, Mouth Irritation, Myocardial Infarction, Nephrotic Syndrome, Nephrotoxicity, Nervousness, Neutropenic Disorder, Non-Infective Meningitis, Oliguria, Palpitations, Pancytopenia, Peripheral Neuropathy, Proteinuria, Psychotic Disorder, Renal Disease, Renal Failure, Scotomata, Seizure Disorder, Skin Photosensitivity, Stevens-Johnson Syndrome, Tachyarrhythmia, Thrombocytopenic Disorder, Toxic Amblyopia, Toxic Epidermal Necrolysis, Tremors, Urticaria, Visual Changes, Vomiting, Weight Loss, Wheezing, Xerostomia

Most Significant
Gastrointestinal Hemorrhage, Post-operative from CABG Surgery, Pregnancy

Significant
Alcoholism, Blood Coagulation Disorder, Bloody Vomit, Body Fluid Retention, Cerebrovascular Accident, Chronic Heart Failure, Disease of Cardiovascular System, Drug-Induced Hepatitis, Gastrointestinal Perforation, Gastrointestinal Ulcer, Hypertension, Increased Cardiovascular Event Risk, Myocardial Infarction, Peptic Ulcer, Severe Renal Disease, Tobacco Smoker

Possibly Significant
Abnormal Hepatic Function Tests, Anemia, Bronchial Asthma, Dehydration, Disease of Liver, Edema