Parameter	Imatinib	Imatinib + St. John's Wort	p Value
Cmax (µg/ml)	1.80 (0.88-2.6)	1.28 (0.92-2.0)	0.005
Tmax (hrs)	2.5 (1-4)	2.5 (1-8)	0.8381
AUC0-(µg•hr/ml)	28.9 (13.4-36.7)	19.7 (10.7-25.0)	0.0001
Half-life (hrs)	13.5 (10.8-18.1)	10.7 (9.1-13.5)	0.0001
Cl/F (L/hr)	13.8 (10.9-29.8)	20.3 (16.0-37.4)	0.00001
Clast (µg/ml)	0.11 (0.05-0.17)	0.05 (0.03-0.12)	0.00002
Protein binding (%)	95.0 (90.3-97.7)	95.1 (90.9-97.3)	0.4737

Data are median (range).
p values determined by paired t test on log-transformed data or Wilcoxon signed rank test for T_max.
C_max = maximum observed concentration; T_max = time to maximum observed concentration; AUC_0- = area under the concentration-time curve from time zero to infinity; Cl/F = apparent oral clearance; C_last = concentration at last observed time point.