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References for:
Enigmatic Kikuchi-Fujimoto Disease: A Comprehensive Review

[Am J Clin Pathol 122(1):141-152, 2004. © 2004 American Society for Clinical Pathology]

  1. Dorfman RF. Histiocytic necrotizing lymphadenitis of Kikuchi and Fujimoto [editorial]. Arch Pathol Lab Med. 1987;111:1026-1029.
  2. Unger PD, Rappaport KM, Strauchen JA. Necrotizing lymphadenitis (Kikuchi's disease): report of four cases of an unusual pseudo-lymphomatous lesion and immunologic marker studies. Arch Pathol Lab Med. 1987;111:1031-1034.
  3. Ahmad M, Khan AB, Iqbal J. Histiocytic necrotizing lymphadenitis: a clinicopathological study. J Pak Med Assoc. 1991;41:86-88.
  4. Kutty MK, Anim JT, Sowayan S. Histiocytic necrotising lymphadenitis (Kikuchi-Fujimoto disease) in Saudi Arabia. Trop Geogr Med. 1991;43:68-75.
  5. Suseelan AV, Augusty TS, Harilal KR. Necrotizing lymphadenitis: an analysis of 17 cases. Indian J Pathol Microbiol. 1984;27:331-334.
  6. Pileri S, Kikuchi M, Helbron D, et al. Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch A Pathol Anat Histopathol. 1982;395:257-271.
  7. Turner RR, Martin J, Dorfman RF. Necrotizing lymphadenitis: a study of 30 cases. Am J Surg Pathol. 1983;7:115-123.
  8. Au MH, Horton LWL. Necrotizing lymphadenitis without granulocytic infiltration (Kikuchi's disease). J Clin Pathol. 1985;38:1252-1257.
  9. Papadimitriou CS, Papacharalampous NX. Histiocytic necrotizing lymphadenitis without granulocytic infiltration [letter]. Arch Pathol Lab Med. 1985;109:107-108.
  10. Dorfman RF. Necrotising lymphadenitis without granulocytic infiltration (Kikuchi's disease) [letter]. J Clin Pathol. 1986;39:811-812.
  11. Ma DD, Hollis RR, Delbridge L. Histiocytic necrotizing lymphadenitis (Kikuchi's disease). Aust N Z J Med. 1986;16:711-713.
  12. Chan JKC, Saw D. Histiocytic necrotizing lymphadenitis (Kikuchi's disease): a clinicopathologic study of nine cases. Pathology. 1986;18:22-28.
  13. Chan JKC, Ng CS. Kikuchi's histiocytic necrotizing lymphadenitis in the regional lymph nodes of malignant fibrous histiocytoma: causal or coincidental? Histopathology. 1988;12:448-451.
  14. Asano S, Akaike Y, Jinnouchi H, et al. Necrotizing lymph-adenitis: a review of clinicopathological, immunohistochemical and ultrastructural studies. Hematol Oncol. 1990;8:251-260.
  15. Asano S, Akaike Y, Muramatsu T, et al. Necrotizing lymphadenitis: a clinicopathological and immunohistochemical study of four familial cases and five recurrent cases. Virchows Arch A Pathol Anat Histopathol. 1991;418:215-223.
  16. Tsang WYW, Chan JKC, Ng CS. Kikuchi's lymphadenitis: a morphologic analysis of 75 cases with special reference to unusual features. Am J Surg Pathol. 1994;18:219-231.
  17. Kuo T. Kikuchi's disease (histiocytic necrotizing lymphadenitis): a clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol. 1995;19:798-809.
  18. Case Records of the Massachusetts General Hospital (Case 5-1997). N Engl J Med. 1997;336:492-499.
  19. Yen A, Fearneyhough P, Raimer SS, et al. EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations. J Am Acad Dermatol. 1997;36:342-346.
  20. Dorfman RF, Berry GJ. Kikuchi's histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol. 1988;5:329-345.
  21. O'Neill D, O'Grady J, Variend S. Child fatality associated with pathological features of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). Pediatr Pathol Lab Med. 1998;18:79-88.
  22. Lin HC, Su CY, Huang CC, et al. Kikuchi's disease: a review and analysis of 61 cases. Otolaryngol Head Neck Surg. 2003;128:650-653.
  23. Feller AC, Lennert K, Stein H, et al. Immunohistochemistry and etiology of histiocytic necrotizing lymphadenitis: report of three instructive cases. Histopathology. 1983;7:825-839.
  24. Heikens J, Tel W, van de Stadt J, et al. Kikuchi's lymphadenitis: report of a Yersinia enterocolitica-associated case and an overview of aetiology and clinical outcome. Neth J Med. 1992;41:222-228.
  25. Kikuchi M, Yoshizumi T, Nakamura H. Necrotizing lymphadenitis: possible acute toxoplasmic infection. Virchows Arch A Pathol Anat Histopathol. 1977;376:247-253.
  26. Chiu CF, Chow KC, Lin TY, et al. Virus infection in patients with histiocytic necrotizing lymphadenitis in Taiwan: detection of Epstein-Barr virus, type I human T-cell lymphotropic virus, and parvovirus B19. Am J Clin Pathol. 2000;113:774-781.
  27. Hollingsworth HC, Peiper SC, Weiss LM, et al. An investigation of the viral pathogenesis of Kikuchi-Fujimoto disease: lack of evidence for Epstein-Barr virus or human herpesvirus type 6 as the causative agents. Arch Pathol Lab Med. 1994;118:134-140.
  28. Cho KJ, Lee SS, Khang SK. Histiocytic necrotizing lymphadenitis: a clinicopathologic study of 45 cases with in situ hybridization for Epstein-Barr virus and hepatitis B virus. J Korean Med Sci. 1996;11:409-414.
  29. Georges TI, Jones CD, Zehnder JL, et al. Lack of human herpesvirus 8 and Epstein-Barr virus in Kikuchi's histiocytic necrotizing lymphadenitis. Hum Pathol. 2003;34:130-135.
  30. Sumiyoshi Y, Kikuchi M, Minematu T, et al. Analysis of herpesvirus genomes in Kikuchi's disease. Virchows Arch. 1994;424:437-440.
  31. Huh J, Chi HS, Kim SS, et al. A study of the viral etiology of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). J Korean Med Sci. 1998;13:27-30.
  32. Sumiyoshi Y, Kikuchi M, Ohshima K, et al. Human herpesvirus-6 genomes in histiocytic necrotizing lymphadenitis (Kikuchi's disease) and other forms of lymphadenitis. Am J Clin Pathol. 1993;99:609-614.
  33. Huh J, Kang GH, Gong G, et al. HHV 8 DNA sequences in Kikuchi's disease [abstract]. Mod Pathol. 1998;11(suppl 1):131A.
  34. Bataille V, Harland CC, Behrens J, et al. Kikuchi disease (histiocytic necrotizing lymphadenitis) in association with HTLV1. Br J Dermatol. 1997;136:610-612.
  35. Atarashi K, Yoshimura N, Nodera H, et al. Recurrent histiocytic necrotizing lymphadenitis (Kikuchi's disease) in a human T lymphotropic virus type 1 carrier. Intern Med. 1996;35:821-825.
  36. Yufu Y, Matsumoto M, Miyamura T, et al. Parvovirus B19-associated haemophagocytic syndrome with lymphadenopathy resembling histiocytic necrotizing lymphadenitis (Kikuchi's disease). Br J Haematol. 1997;96:868-871.
  37. Tanaka T, Ohmori M, Yasunaga S, et al. DNA typing of HLA class II genes (HLA-DR, -DQ and -DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi's disease). Tissue Antigens. 1999;54:246-253.
  38. Imamura M, Ueno H, Matsuura A, et al. An ultrastructural study of subacute necrotizing lymphadenitis. Am J Pathol. 1982;107:292-299.
  39. Charalabopoulos K, Charalabopoulos A, Binolis J, et al. Is implant pacemaker a physicochemical cause triggering Kikuchi-Fujimoto disease? In Vivo. 2002;16:73-76.
  40. Sever CE, Leith CP, Appenzehler J, et al. Kikuchi's histiocytic necrotizing lymphadenitis associated with ruptured silicone breast implant. Arch Pathol Lab Med. 1996;120:380-385.
  41. Felgar RE, Furth EE, Wasik MA, et al. Histiocytic necrotizing lymphadenitis (Kikuchi's disease): in situ end-labeling, immunohistochemical, and serologic evidence supporting cytotoxic lymphocyte-mediated apoptotic cell death. Mod Pathol. 1997;10:231-241.
  42. Takakuwa T, Ohnuma S, Koike J. Involvement of cell-mediated killing in apoptosis in histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). Histopathology. 1996;28:41-48.
  43. Ohshima K, Shimazaki K, Suzumiya J, et al. Apoptosis of cytotoxic T-cells in histiocytic necrotizing lymphadenitis. Virchows Arch. 1998;433:131-134.
  44. Liu Q, Ohshima K, Shinohara T, et al. Apoptosis in histiocytic necrotizing lymphadenitis. Pathol Int. 1995;45:729-734.
  45. Ohshima K, Shimazaki K, Kume T, et al. Perforin and Fas pathways of cytotoxic T-cells in histiocytic necrotizing lymphadenitis. Histopathology. 1998;33:471-478.
  46. Sumiyoshi Y, Kikuchi M, Takeshita M, et al. Immunohistologic studies of Kikuchi's disease. Hum Pathol. 1993;24:1114-1119.
  47. Hansmann ML, Kikuchi M, Wacker HH, et al. Immunohistochemical monitoring of plasmacytoid cells in lymph node sections of Kikuchi-Fujimoto disease by a new panmacrophage antibody K1M1P. Hum Pathol. 1992;23:676-680.
  48. Facchetti F, de Wolf-Peeters C, van den Oord JJ, et al. Plasmacytoid monocytes (so-called plasmacytoid T-cells) in Kikuchi's lymphadenitis: an immunohistologic study. Am J Clin Pathol. 1989;92:42-50.
  49. Pileri SA, Fachetti F, Ascani S, et al. Myeloperoxidase expression by histiocytes in Kikuchi's and Kikuchi-like lymphadenopathy. Am J Pathol. 2001;159:915-924.
  50. Galibert L, Maliszewski CR, Vandenabeele S. Plasmacytoid monocytes/T cells: a dendritic cell lineage? Semin Immunol. 2001;13:283-289.
  51. Comeau MR, Van der Vuurst de Vries AR, Maliszewski CR, et al. CD123bright plasmacytoid predendritic cells: progenitors undergoing cell fate conversion? J Immunol. 2002;169:75-83.
  52. Abe Y, Ohshima K, Nakashima M, et al. Expression of apoptosis-associated protein RCAS1 in macrophages of histiocytic necrotizing lymphadenitis. Int J Hematol. 2003;77:359-363.
  53. Kubota M, Tsukamoto R, Kurokawa K, et al. Elevated serum interferon gamma and interleukin-6 in patients with necrotizing lymphadenitis (Kikuchi's disease). Br J Haematol. 1996;95:613-615.
  54. Kato K, Ohshima K, Anzai K, et al. Elevated serum-soluble Fas ligand in histiocytic necrotizing lymphadenitis. Int J Hematol. 2001;73:84-86.
  55. Ohshima K, Haraoka S, Takahata Y, et al. Interferon-gamma, interleukin-18, monokine induced by interferon gamma and interferon-gamma-inducible protein-10 in histiocytic necrotizing lymphadenitis. Leuk Lymphoma. 2002;43:1115-1120.
  56. Kuo TT. Cutaneous manifestations of Kikuchi's histiocytic necrotizing lymphadenitis. Am J Surg Pathol. 1990;14:872-876.
  57. Sumiyoshi Y, Kikuchi M, Ohshima K, et al. A case of histiocytic necrotizing lymphadenitis with bone marrow and skin involvement. Virchows Arch A Pathol Anat Histopathol. 1992;420:275-279.
  58. Sumiyoshi Y, Kikuchi M, Takeshita M, et al. Immunohistological study of skin involvement in Kikuchi's disease. Virchows Arch B Cell Pathol Incl Mol Pathol. 1992;62:263-269.
  59. Yasukawa K, Matsumura T, Sato-Matsumura KC, et al. Kikuchi's disease and the skin: case report and review of the literature. Br J Dermatol. 2001;144:885-889.
  60. Aquel N, Henry K, Woodrow D. Skin involvement in Kikuchi's disease: an immunocytochemical and immunofluorescence study. Virchows Arch. 1997;430:349-352.
  61. Kikuchi M, Takeshita M, Eimoto T, et al. Histiocytic necrotizing lymphadenitis: clinicopathologic, immunologic, and HLA typing study. In: Hanaoka M, Kadin ME, Mikata A, et al, eds. Lymphoid Malignancy: Immunocytology and Cytogenetics. New York, NY: Field & Wood Medical; 1990:251-257.
  62. Kaur S, Thami GP, Mohan H, et al. Kikuchi disease with facial rash and erythema multiforme. Pediatr Dermatol. 2001;18:403-405.
  63. Spies J, Foucar K, Thompson C, et al. The histopathology of cutaneous lesions of Kikuchi's disease: a report of 5 cases. Am J Surg Pathol. 1999;23:1040-1047.
  64. Kim KJ, Jee MS, Chang SE, et al. Kikuchi-Fujimoto disease with papulopustular skin manifestations. Clin Exp Dermatol. 2003;28:142-144.
  65. Imai K, Yokozeki H, Nishioka K. Kikuchi's disease (histiocytic necrotizing lymphadenitis) with cutaneous involvement. J Dermatol. 2002;29:587-592.
  66. Kato A, Kono T, Ishii M, et al. Spontaneous clearance of psoriasis during the course of Kikuchi-Fujimoto disease. J Am Acad Dermatol. 2002;47(5 suppl):S287-S288.
  67. Pearl D, Strauchen JA. Kikuchi's disease as a cause of fever of unknown origin [letter]. N Engl J Med. 1989;320:1147-1148.
  68. Bailey EM, Klein NC, Cunha BA. Kikuchi's disease with liver dysfunction presenting as fever of unknown origin [letter]. Lancet. 1989;2:986.
  69. Kapadia Y, Robinson BA, Angus HB. Kikuchi's disease presenting as fever of unknown origin [letter]. Lancet. 1989;2:1519-1520.
  70. Pasquinucci S, Dionisi PM, Cavinato F, et al. Kikuchi's disease in a patient infected with AIDS [letter]. AIDS. 1991;5:235.
  71. Vasallo J, Coehlo Filho JC, Amaral VG. Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV positive patient. Rev Inst Med Trop Sao Paulo. 2002;44:265-268.
  72. Charalabopoulos K, Papalimneou V, Charalabopoulos A, et al. Brucella melitensis infection stimulates an immune response leading to Kikuchi-Fujimoto disease. In Vivo. 2003;17:51-53.
  73. Maek-a-nantawat W, Viriyavejakul P. Mycobacterium szulgai lymphadenitis mimicking Kikuchi's disease in Thailand. Southeast Asian J Trop Med Public Health. 2001;32:537-540.
  74. el-Ramahi KM, Karrar A, Ah MA. Kikuchi disease and its association with systemic lupus erythematosus. Lupus. 1994;3:409-411.
  75. Martinez-Vazquez C, Hughes G, Bordon J, et al. Histiocytic necrotizing lymphadenitis, Kikuchi-Fujimoto's disease, associated with systemic lupus erythematosus. QJM. 1997;90:531-533.
  76. Litwin MD, Kirkham B, Henderson DRF, et al. Histiocytic necrotising lymphadenitis in systemic lupus erythematosus. Ann Rheum Dis. 1992;151:805-807.
  77. Tumiati B, Bellelli A, Portioli I, et al. Kikuchi's disease in systemic lupus erythematosus: an independent or dependent event? Clin Rheumatol. 1991;10:90-93.
  78. Hu S, Kuo TT, Hong HS. Lupus lymphadenitis simulating Kikuchi's lymphadenitis in patients with systemic lupus erythematosus: a clinicopathological analysis of six cases and review of the literature. Pathol Int. 2003;53:221-226.
  79. Pappaioannou G, Speletas M, Kaloutsi V, et al. Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) associated with antiphospholipid syndrome: case report and literature review. Ann Hematol. 2002;81:732-735.
  80. Wilkinson CE, Nichol F. Kikuchi-Fujimoto disease associated with polymyositis. Rheumatology (Oxford). 2000;39:1302-1304.
  81. Ramanan AV, Wynn RF, Kelsey A, et al. Systemic juvenile idiopathic arthritis, Kikuchi's disease and haemophagocytic lymphohistiocytosis: is there a link? case report and review of the literature. Rheumatology (Oxford). 2003;42:596-598.
  82. Taguri AH, McIlwaine GG. Bilateral panuveitis: a possible association with Kikuchi-Fujimoto disease. Am J Ophthalmol. 2001;132:419-421.
  83. Graham LE. Kikuchi-Fujimoto disease and peripheral arthritis: a first [letter]! Ann Rheum Dis. 2002;61:475.
  84. Belagavi CS, Kubeyinje EP. Recurrent cutaneous necrotizing vasculitis in a patient with Kikuchi's disease: case report. East Afr Med J. 1997;74:747-748.
  85. Wong CY, Law GT, Shum TT, et al. Pulmonary haemorrhage in a patient with Kikuchi disease. Monaldi Arch Chest Dis. 2001;56:118-120.
  86. Quintas-Cardama A, Fraga M, Cozzi SN, et al. Fatal Kikuchi-Fujimoto disease: the lupus connection. Ann Hematol. 2003;82:186-188.
  87. Laccourreye O, Kugelstadt P, Hugues FC, et al. Intraparotid subacute necrotizing histiocytic lymphadenitis (Kikuchi-Fujimoto's disease). J Otolaryngol. 1997;26:64-66.
  88. Keogh MA, Williamson RM, Denaro CP. Kikuchi's disease associated with parotidomegaly, thyroiditis and a rash in a young man [letter]. Aust N Z J Med. 2000;30:633-634.
  89. Radhi JM, Skinnider L, McFadden A. Kikuchi's lymph-adenitis and carcinoma of the stomach. J Clin Pathol. 1997;50:530-531.
  90. Yoshino T, Mannami T, Ichimura K, et al. Two cases of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto's disease) following diffuse large B-cell lymphoma. Hum Pathol. 2000;31:1328-1331.
  91. Kelly J, Kelleher K, Khan MK. A case of haemophagocytic syndrome and Kikuchi-Fujimoto disease occurring concurrently in a 17-year-old female. Int J Clin Pract. 2000;54:547-549.
  92. Mahadeva U, Allport T, Bain B, et al. Haemophagocytic syndrome and histiocytic necrotising lymphadenitis (Kikuchi's disease). J Clin Pathol. 2000;53:636-638.
  93. Na DG, Chung TS, Byun HS, et al. Kikuchi disease: CT and MR findings. AJNR Am J Neuroradiol. 1997;18:1729-1732.
  94. Fulcher AS. Cervical lymphadenopathy due to Kikuchi disease: US and CT appearance. J Comput Assist Tomogr. 1993;17:131-133.
  95. Ogawa M, Ueda S, Ohto M, et al. Ultrasonography of cervical lymphadenopathy in a patient with Kikuchi's disease. Acta Radiol. 1991;32:260-261.
  96. Miller WT Jr, Perez-Jaffe LA. Cross-sectional imaging of Kikuchi disease. J Comput Assist Tomogr. 1999;23:548-551.
  97. Tsang WYW, Chan JKC. Fine-needle aspiration cytologic diagnosis of Kikuchi's lymphadenitis: a report of 27 cases. Am J Clin Pathol. 1994;102:454-458.
  98. Hsueh EJ, Ko WS, Hwang WS. Fine-needle aspiration of histiocytic necrotizing lymphadenitis (Kikuchi's disease). Diagn Cytopathol. 1993;9:448-452.
  99. Kung ITM, Ng WF, Yuen RWS, et al. Kikuchi's histiocytic necrotizing lymphadenitis: diagnosis by fine-needle aspiration. Acta Cytol. 1990;34:323-328.
  100. Viguer JM, Jimenez-Heffernan JA, Perez P, et al. Fine-needle aspiration cytology of Kikuchi's lymphadenitis: a report of ten cases. Diagn Cytopathol. 2001;25:220-224.
  101. Tong TR, Chan OW, Lee KC. Diagnosing Kikuchi disease on fine needle aspiration biopsy: a retrospective study of 44 cases diagnosed by cytology and 8 by histopathology. Acta Cytol. 2001;45:953-957.
  102. Chamulak GA, Brynes R, Nathwani BN. Kikuchi-Fujimoto disease mimicking malignant lymphoma. Am J Surg Pathol. 1990;14:514-523.
  103. Dylewski J, Berry G, Pham-Dang H. An unusual cause of cervical lymphadenitis: Kikuchi-Fujimoto disease. Rev Infect Dis. 1991;13:823-825.
  104. Baddoura FK, Hanson C, Chan WC. Plasmacytoid monocyte proliferation associated with myeloproliferative disorders. Cancer. 1992;69:1457-1467.
  105. Menasce LP, Banerjee SS, Edmondson D, et al. Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): continuing diagnostic difficulties. Histopathology. 1998;33:248-254.
  106. Smith KGC, Becker GJ, Busmanis I. Recurrent Kikuchi's disease [letter]. Lancet. 1992;340:124.
  107. Blewitt RW, Kumar SN, Abraham JS. Recurrence of Kikuchi's lymphadenitis after 12 years. J Clin Pathol. 2000;53:157-158.
  108. Chan JK, Wong KC, Ng CS. A fatal case of multicentric Kikuchi's histiocytic necrotizing lymphadenitis. Cancer. 1989;63:1856-1862.
  109. Tsai MK, Huang HF, Hu RH, et al. Fatal Kikuchi-Fujimoto disease in transplant recipients: a case report. Transplant Proc. 1998;30:3137-3138.
  110. Jang YJ, Park KH, Seok HJ. Management of Kikuchi's disease using glucocorticoid. J Laryngol Otol. 2000;114:709-711.
  111. Takada, Sukuzi K, Hidaka T. Immediate remission obtained by minocycline in a patient with histiocytic necrotizing lymphadenitis. Intern Med. 2001;40:1055-1058.