| Indication | Drug and Dosage |
| Initial genital infection | Acyclovir 400 mg PO 5 times daily or valacyclovir 1 g PO 3 times daily, for 10 days |
| Recurrent genital infection | Acyclovir 400 mg PO 5 times daily or valacyclovir 1 g PO 2 times daily, for 5 days |
| Suppression of recurrent genital infection | Acyclovir 400 mg PO 2 or 3 times daily or valacyclovir 1 g PO once daily |
| Herpes labialis | Penciclovir 1% topically every 2 h for 4 days or acyclovir 400 mg PO 5 times daily for 5 days |
| Encephalitis | Acyclovir 10-15 mg/kg IV every 8 h for 14-21 days |