A) Primary glomerular diseases frequently recur and are commonly associated with graft loss is correct.

 

Key Concept/Objective: To understand the risk of disease recurrence in patients with primary glomerular disease

The recurrence rates of different primary renal diseases vary. Primary glomerular diseases frequently recur in the transplanted kidney; however, graft loss secondary to recurrence is uncommon. The patients who are at greatest risk of graft loss are those in whom renal function deteriorated rapidly and aggressively. In these patients, transplantation may be relatively contraindicated. Lupus nephritis, anti-GBM disease, and membranous nephropathy have low recurrence rates and are rarely associated with graft loss. Type II membranoproliferative disease has a high recurrence rate (80% to 90%); however, it too is associated with a low incidence of graft loss. Patients with Alport syndrome can develop anti-GBM disease in the allograft, although this is uncommon, and Alport syndrome is not a contraindication to transplantation.