Test	Serum Concentrationa
	Before Infliximab	After Infliximab
Patient 1
Alanine transaminase (units/L)	25	45
Aspartate transaminase (units/L)	28	47
Alkaline phosphatase (units/L)	159	146
Lactate dehydrogenase (units/L)b	465	412
Total bilirubin (mg/dL)	0.10	0.12
Direct bilirubin (mg/dL)	0.05	0.04
Patient 2
Alanine transaminase (units/L)	49	58
Aspartate transaminase (units/L)	36	39
-glutamyl transferase (units/L)	. . .	665
Alkaline phosphatase (units/L)c	357	428
Total bilirubin (mg/dL)	0.34	0.16
Direct bilirubin (mg/dL)	0.11	0.33
Patient 3
Alanine transaminase (units/L)	165	56
Aspartate transaminase (units/L)	65	18
Lactate dehydrogenase (units/L)	371	745
Total bilirubin (mg/dL)	4.63	1.67
Direct bilirubin (mg/dL)	3.38	0.55
Patient 4
Alanine transaminase (units/L)	35	62
Aspartate transaminase (units/L)	20	62
Alkaline phosphatase (units/L)	83	100
Total bilirubin (mg/dL)	0.21	0.40
Direct bilirubin (mg/dL)	0.06	. . .

^aNormal values: alanine transaminase, 0-35 units/ L; aspartate transaminase, 0-35 units/L; alkaline phosphatase, 30-114 units/L; lactate dehydrogenase, 118-242 units/L; total bilirubin, <1.2 mg/dL; direct bilirubin, <0.2 mg/dL; -glutamyl transferase, 0-33 units/ L (females) or 11-51 units/L (males).
^bElevated lactate dehydrogenase concentrations are neither sensitive nor specific indicators of liver damage. Since the results of other tests in patient 1 were normal or only mildly elevated, the elevated lactate dehydrogenase concentrations were judged not to indicate liver involvement.
^cBecause of the concurrently elevated -glutamyl transferase concentration, the elevated alkaline phosphatase concentrations were judged to indicate liver involvement.