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Tables for:
Long-Term Efficacy and Tolerability of Rizatriptan Wafers in Migraine

[Medscape General Medicine 3(2), 2001. © 2001 Medscape Portals, Inc]


Table 1. Patient Characteristics


 Rizatriptan
10 mg (n = 181)
Rizatriptan
5 mg (n = 191)
Standard Care
(n = 86)
Mean age (y)424343
% female918788
% white989898
% using prophylactics313128
% using oral contraceptives or hormone replacement383942
Mean baseline headache severity*2.42.32.4
Mean number of attacks treated191718
Mean number of days in study167183174

*Baseline severity represents a patients's average baseline severity over all attacks; 2 = moderate, 3 = severe.


Table 2. Odds Ratios (95% CI) for Percentage of Patients' Headaches With Pain Relief or Pain Free at 2 Hours


Treatment GroupPain ReliefPain Free
vs Standard Carevs Rizatriptan
5 mg
vs Standard Carevs Rizatriptan
5 mg
Rizatriptan
10 mg
1.63
(1.14 - 2.34)
1.60
(1.23 - 2.08)
1.50*
(1.06 - 2.12)
1.93
(1.50 - 2.49)
Rizatriptan
5 mg
1.02
(0.72-1.45)
-- 0.78
(0.55 - 1.10)
-

*P < .05.
P < .01.
P < .001


Table 3. Clinical Adverse Events With an Incidence >= 5% in any 1 Treatment Group


Adverse EventRizatriptan 10 mg
(n = 181)
Rizatriptan 5 mg
(n = 191)
Standard Care
(n = 86)
Abdominal pain4%2%6%
Asthenia/fatigue4%2%9%
Back pain2%2%*7%
Dizziness6%4%9%
Headache3%2%6%
Nausea8%5%*13%
Pharyngeal discomfort1%*0%6%
Somnolence6%4%6%
Upper respiratory infection7%4%*11%
Vomiting3%1%*7%

*P < .05 vs standard care.
P < .01 vs standard care.