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Class Drugs TCAs and related compounds Amineptine, amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, trazodone MAOIs Isocarboxazid, phenelzine, tranylcypromine SSRIs Citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline Miscellaneous antidepressants Venlafaxine, nefazodone, mirtazapine TCA = tricyclic antidepressant; MAOI = monoamine oxidase inhibitor; SSRI = selective serotonin reuptake inhibitor.
Symptom group Common symptoms Common feature of
SSRI discontinuation syndromesCommon feature of
TCA discontinuation
syndromesDysequilibrium Light headedness/dizziness, vertigo, ataxia Sensory symptoms Paraesthesia, numbness, electric shock-like sensations General somatic symptoms Lethargy, headache, tremor, sweating, anorexia Sleep disturbance Insomnia, nightmares, excessive dreaming Gastrointestinal symptoms Nausea, vomiting, diarrhoea Affective symptoms Irritability, anxiety/agitation, low mood SSRI = selective serotonin reuptake inhibitor; TCA = tricyclic antidepressant.
