References for:
Benzocaine-Induced Methemoglobinemia During an Outpatient Procedure

[Pharmacotherapy 20(6):735-738, 2000. © 2000 Pharmacotherapy Publications]

  1. Smith R, Olsen M. Drug induced methemoglobinemia. Semin Hematol 1973;10:253-68.
  2. Olson ML, McEvoy GK. Methemoglobinemia induced by local anesthetics. Am J Hosp Pharm 1981;38:89-93.
  3. Spielman FJ, Anderson JA, Terry WC. Benzocaine-induced methemoglobinemia during general anesthesia. J Oral Maxillofac Surg 1984;42:740-3.
  4. Marcovitz PA, Williamson BD, Armstrong WF. Toxic methemoglobinemia caused by topical anesthetic given before transesophageal echocardiography. J Am Soc Echocardiogr 1991;4:615-18.
  5. Ho RT, Nanevicz T, Yee R, Figueredo VM. Benzocaine-Induced methemoglobinemia -- two case reports related to transesophageal echocardiography premedication. Cardiovasc Drugs Ther 1998;12:311-12.
  6. Fisher MA, Henry D, Gillam L, Chen C. Toxic methemoglobinemia: a rare but serious complication of transesophageal echocardiography. Can J Cardiol 1998;14(9):1157-60.
  7. Grauer SE, Giraud GD. Toxic methemoglobinemia after topical anesthesia for transesophageal echocardiography. J Am Soc Echocardiogr 1996;9(6):874-6.
  8. Guerriero SE. Methemoglobinemia caused by topical benzocaine. Pharmacotherapy 1997;17(5):1038-40.
  9. Rodriquez LF, Smolik LM, Zbehlik AJ. Benzocaine-induced methemoglobinemia: report of a severe reaction and review of the literature. Ann Pharmacother 1994;28:643-9.
  10. Douglas WW, Fairbanks VF. Methemoglobinemia induced by a topical anesthetic spray (Cetacaine). Chest 1977;71:587-91.
  11. Catterall W, Mackie K. Local anesthetics. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman, AG, eds. Goodman and Gilman's the pharmacologic basis of therapeutics, 9th ed. New York: McGraw-Hill, 1996:331-47.
  12. Lovejoy FH Jr, Linden CH. Environmental and occupational hazards. In: Wilson JD, Braunwald E, Isselbacher KJ, et al, eds. Harrison's principles of internal medicine, 12th ed. New York: McGraw-Hill, 1991:2177.
  13. Barker SJ, Tremper KK, Hyatt J, Zaccari J. Effects of methemoglobinemia on pulse oximetry and mixed venous oximetry [abstr]. Anesthesiology 1987;67:A171
  14. Anderson ST, Hajduczek J, Barker ST. Benzocaine-induced methemoglobinemia in an adult: accuracy of pulse oximetry with methemoglobinemia. Anesth Analg 1988;67:1099-1101
  15. Scheller MS, Unger RJ. The influence of intravenously administered dyes on pulse oximetry readings [abstr]. Anesthesiology 1986;65:A161.