Reference	Age (years)	Men (%)	Number screened	Diabetes exclusions	Number followed	Study duration (years)	Cardio- vascular deaths (n)	Cardio- vascular events plus deaths (n)	Glucose method	Glucose intervals	Highest glucose interval (mmol/l)
Fasting
Scheidt-Nave    et al. (19)	40-79	43	3,458	DM Hx, BCH	3,458	14	217	217	Plasma	7	7.2-7.7
Shaten    et al. (24)	35-57	100	12,866	DM meds	12,694	10.5	426	426	Serum	6	>=7.8
Yarnell    et al. (29)	45-59	100	4,860	DM Hx	4,349	4	NA	209	Plasma	5	>=7.8
Schroll and    Hagerup (30)	50	100	388	DM Hx	383	10	18	18	Blood	5	5.3-12.5
Ohlson    et al. (31)	73	100	973	DM Hx, BCH	832	17	N/A	141	Whole blood	5	>5
Pyorala    et al. (16,65)	40-59	100	1,059	DM Hx	845	10	42	42	Blood	5	5.2-15.2
2-h (dose)*
Stamler et al.    (14) (100 g)	42-58	100	1,694	DM Hx	1,694	15	166	166	Plasma	5	6.7-23.3
Pyorala et al.    (16,65)    (75-90 g)	40-59	100	1,059	DM Hx	845	10	42	42	Blood	5	5.6-18.5
Fuller et al.    (17) (50 g)	40-64	100	18,403	DM Hx	18,106	15	915	915	Capillary	5	4.8-11.1
Balkau et al.    (21) (75 g)	44-55	100	7,166	DM Hx	7,038	15.6	167	167	Blood	3	>=11.1
Da Silva et al.    (25) (100 g)	40-59	100	1,499	DM Hx	1,491	5	12	12	Capillary	5	6.8-17.8
Grabauskas    (33) (75 g)	45-59	100	2,455	DMHx	2,413	10	114	114	Plasma	5	10-17.8
Tuomilehto    et al.    (22) (75 g)	240	43	1,537	NA	1,537	5	51	51	Capillary	3	>=11.1
1-h (dose)*
Stenhouse    et al.    (15) (50 g)	40-59	100	3,331	DM Hx	638	11	21	21	Plasma	5	6.8-2
Donahue    et al.    (18) (50 g)	45-70	100	6,394	DM Hx	6,394	12	119	303	Serum	5	10.6-29 6
Vaccaro    et al.    (20) (50 g)	34-65	100	873	DM Hx	873	19	144	144	Plasma	5	11.7 (mean)
Reunanen    et al.    (27)    (60-90 g)	40-59	100	3,351	DM Hx	3,267	4	64	64	Plasma	5	10.8-28.1
Pyorala    et al.    (16,65)    (75-90 g)	40-59	100	1,059	DM Hx	845	10	42	42	Blood	5	8.0-20.3
Casual
Perry    et al. (23)	40-59	100	7,735	DM Hx, BCH	7,177	9.5	222	505	Serum	5	>=26
Hawthorne    and Gilmour    (26)	45-64	100	1,134	DM Hx	1,128	6	29	29	Whole blood	5	6.0-28.8
Cruz-Vidal    et al. (28)	45-64	100	8,248	DM meds	5,445	8.25	83	83	Whole blood	5	7.8-34.2
Lund Haheim    et al. (32)	40-49	100	16,172	DM Hx .	16,021	18	80	80	Serum	5	26.2
All studies	20-84	-	112,311†	-	95,783†	12.4	3,074†	3,707†	-	-	-

BCH, biochemical criteria for diabetes using the measured glucose level; DM Hx, history of diabetes; DM meds, on diabetes medications: NA. not available.

*	Dose of oral glucose given.
†	Does not include any study more than once.

Reference	Person-years	Cardiovascular events		Cardiovascular mortality		Independent effects
		ß-coefficient (95% Cl)	P value*	ß-coefficient (95% Cl)	P value*	Glucose† (P value)	Insulin (P value)
Fasting
Scheidt-Nave    et al. (19)	48,412	1.386 (0.646 to 2.126)	0.0003	1.386 (0.646 to 2.126)	0.0003	<0.02a,b,c,d,e,f,‡	NA
Shaten    et al. (24)	133,287	0.400 (-0.227 to 1.026)	0.22	0.400 (-0.227 to 1.026)	0.22	<0 01abcdf§	NA
Yarnell    et al. (29)	17,396	1.320 (0.451 to 2.189)	0.0055	NA	NA	NSbcdef	NA
Schroll and    Hagerup (30)	3,830	-0.003 (-1.052 to 1.046)	0.995	-0.003 (-1.052 to 1.046)	0.995	NSbcde	NS
Ohlson    et al. (31)	14,144	-0.339 (-2.146 to 1.469)	0.71	NA	NA	NA	NA
Pyorala    et al. (16,65)	8,450	0.280 (-0.204 to 0.764)	0.27	0.280 (-0.204 to 0.764)	0.27	NSabcde	<O.01
All	225,519	0.606 (0.113 to 1.099)	0.016	0.531 (-0.006 to 1.067)	0.052	-	-
2-h
Stamler    et al. (14)	25,410	0.021 (-0.126 to 0.168)	0.78	0.021 (-0.126 to 0.168)	0.78	NSabcde	NA
Pyorala    et al. (16,65)	8,450	0.392 (0.067 to 0.716)	0.023	0.392 (0.067 to 0.716)	0.023	NSabcde	<0.01
Fuller    et al. (17)	271,590	0.792 (0.580 to 1.004)	<0.0001	0.792 (0.580 to 1.004)	<0.0001	NA	NA
Balkau    et al. (21)	109,792.8	1.111 (0.407 to 1.816)	0.005	1.111 (0.407 to 1.816)	0.005	NA	<0.005
Da Silva    et al. (25)	7,455	0.201 (-0.520 to 0.922)	0.59	0.201 (-0.520 to 0.922)	0.59	NSabcde	NA
Grabauskas (33)	24,130	0.470 (0.232 to 0.707)	0.0002	0.470 (0.232 to 0.707)	0.0002	<0 01abcdf	NA
Tuomilehto    et al. (22)	7,685	1.095 (0.362 to 1.829)	0.005	1.095 (0.362 to 1.829)	0.005	NA	NA
All	454,512.8	0.531 (0.204 to 0.858)	0.0015	0.531 (0.204 to 0.858)	0.0015	-	-
1-h
Stenhouse    et al. (15)	7,018	0.102 (-0.305 to 0.509)	0.63	0.102 (-0.305 to 0.509)	0.63	NSabcde	NA
Donahue    et al. (18)	76,728	0.136 (0.057 to 0.215)	0.001	0.278 (0.159 to 0.397)	<0.0001	<0.01abcdef	NA
Vaccaro    et al. (20)	16,587	0.501 (0.207 to 0.795)	0.001	0.501 (0.207 to 0.795)	0.001	<0.05abcdef	NA
Reunanen    et al. (27)	13,068	0.114 (-0.068 to 0.296)	0.23	0.114 (-0.068 to 0.296)	0.23	NSabcde	NA
Pyorala    et al. (16,65)	8,450	0.499 (0.197 to 0.801)	0.002	0.499 (0.197 to 0.801)	0.002	NSabcde	<0.01
All	121,851	0.242 (0.084 to 0.400)	0.0013	0.287 (0.140 to 0.433)	0.0001	-	-
Casual
Perry    et al. (23)	68,181.5	0.616 (-0.148 to 1.380)	0.12	-0.255 (-1.417 to 0.907)	0.67	NA	NA
Hawthorne and    Gilmour (26)	6,768	0.073 (-0.202 to 0.348)	0.61	0.073 (-0.202 to 0.348)	0.61	NSabcde	NA
Cluz-Vidal    et al. (28)	44,921.3	0.248 (0.032 to 0.465)	0.046	0.248 (0.032 to 0.464)	0.046	NA	NA
Lund Haheim    et al. (32)	288,378	1.026 (-0.935 to 2.978)	0.31	1.026 (-0.935 to 2.978)	0.31	NSac	NA
All	408,248.8	0.157 (-0.092 to 0.405)	0.22	0.085 (-0.172 to 0.341)	0.052	-	-

*	Goodness of fit.
†	P values are shown for studies that calculated the incremental effect of increasing glucose levels on the risk of cardiovascular or total mortality alter statistical adjustment for one or more cardiovascular risk factors including: a age, b blood pressure (systolic or diastolic), c BMI or weight, d lipids, e smoking, or f other risk factors.
‡	The P value was significant in men across glucose ranges and in women for glucose values >=6.1 mmol/l (11O mg/dl) only;
§	The P value was significant for nonsmokers.

NA, not available.

Reference	Cardiovascular events
	ß-coefficient (95% Cl)	P value*
Fasting
Scheidt-Nave et al. (19)	1.203 (0.328 to 2.079)	0.007
Shaten et al. (24)	0.083 (-0.660 to 0.826)	0.827
Yarnell et al. (29)	1.346 (0.245 to 2.448)	0.023
All	0.817 (-0.020 to 1.655)	0.056
2-h
Balkau et al. (21)	1.157 (0.029 to 2.284)	0.057
Grabauskas et al. (33)	0.970 (0.251 to 1.688)	0.008
Tuomilehto et al. (22)	1.128 (-1.530 to 3.785)	0.432
All	1.029 (0.438 to 1.620)	0.0006

*	Goodness of fit.