Medscape www.medscape.com

References for:
Treatment of Antidepressant-Induced Sexual Dysfunction

[Medscape Psychiatry & Mental Health eJournal 3(3), 1998. © 1998 Medscape]


  1. Gitlin MJ: Psychotropic medications and their effects on sexual dysfunction: Diagnosis, biology and treatment approaches. J Clin Psychiatry 55:406-413, 1994.
  2. Gitlin MJ: Sexual side effects of psychotropic medications, in Dunner DL, Rosenbaum JF (eds): Psychiatric Clin North Am Annual Drug Ther 4:61-90, 1997.
  3. Nofzinger EA, Thase ME, Reynolds CF, et al: Sexual function in depressed men: Assessment by self-report, behavioral and nocturnal penile tumescence measures before and after treatment with cognitive behavior therapy. Arch Gen Psychiatry 40:24-30, 1993.
  4. Howell JR, Reynolds CF, Thase ME, et al: Assessment of sexual function, interest and activity in depressed men. J Affect Disord 13:61-66, 1987.
  5. Roose SP, Glassman AH, Walsh BT, et al: Reversible loss of nocturnal penile tumescence during depression: A preliminary report. Neuropsychobiology 8:284-288, 1982.
  6. Thase ME, Nofzinger E, Reynolds CF, et al: Effect of antidepressant treatment on sexual function in depressed men. Psychopharmacol Bull 30:83, 1994.
  7. Thase M, Reynolds CF, Glanz LM, et al: Nocturnal penile tumescence in depressed men. Am J Psychiatry 144:89-92, 1987.
  8. Thase ME, Reynolds CF, Jennings JR, et al: Nocturnal penile tumescence is diminished in depressed men. Biol Psychiatry 24:33-46, 1988.
  9. Thase ME, Reynolds CF, Jennings R, et al: Diminished nocturnal tumescence in depression: A replication study. Biol Psychiatry 31:1136-1142, 1992.
  10. Nathan S: The epidemiology of the DSM-III psychosexual dysfunctions. J Sex Marital Ther 12:267-281, 1986.
  11. Sadock VA: Normal human sexuality and sexual dysfunctions, in Kaplan HI, Sadock BJ (eds): Comprehensive Textbook of Psychiatry, ed 6. Baltimore, Williams & Wilkins, 1995, pp 1295-1321.
  12. Casper RC, Redmond DZ, Katz MM, et al: Somatic symptoms in primary affective disorder. Arch Gen Psych 42:1098-1104, 1985.
  13. Ashton AK, Hamer R, Rosen R: Serotonin reuptake inhibitor-induced sexual dysfunction and its treatment: A large-scale retrospective study of 596 psychiatric outpatients. J Sex Marital Ther 23(3):165-175, 1997.
  14. Balon R, Yeragani VK, Pohl R, et al: Sexual dysfunction during antidepressant treatment. J Clin Psychiatry 54:209-212, 1993.
  15. Monteiro WO, Noshirvani HF, Marks IM, et al: Anorgasmia from clomipramine in obsessive-compulsive disorder: A controlled trial. Br J Psychiatry 151:107-112, 1987.
  16. Gartrell N: Increased libido in women receiving trazodone. Am J Psychiatry 143:781-782, 1986.
  17. Modell JG: Repeated observations of yawning, clitoral engorgement, and orgasm associated with fluoxetine administration. J Clin Psychopharmacol 9:63-65, 1989. Letter.
  18. Smith DM, Levitte SS: Association of fluoxetine and return of sexual potency in three elderly men. J Clin Psychiatry 54:317-319, 1993.
  19. Sullivan G: Increased libido in three men treated with trazodone. J Clin Psychiatry 49:202-203, 1988.
  20. Ellison JM: Exercise-induced orgasms associated with fluoxetine treatment of depression. J Clin Psychiatry 57:12 596-597, 1996.
  21. Montejo AL, Llorca G, Izquierdo JA, et al: Sexual dysfunction with SSRIs: A comparative analysis. New Research Programs and Abstracts of the Annual Meeting of the American Psychiatric Association, New York, 1996, p 266. Abstract NR717.
  22. Physician's Desk Reference. Montvale, NJ, Medical Economics Co., 1995.
  23. Hsu JH, Shen WW: Male sexual side effects associated with antidepressants: A descriptive clinical study of 32 patients. Int J Psychiatry Med 25:191-201, 1995.
  24. Shen WW, Hsu JH: Female sexual side effects associated with selective serotonin reuptake inhibitors: A descriptive clinical study of 33 patients. Int J Psychiatry Med 25:239-248, 1995.
  25. Modell JG, Katholi CR, Modell JD, et al: Comparative sexual side effects of bupropion, fluoxetine, paroxetine and sertraline. Clin Pharmacol Ther 61:476-487, 1997.
  26. Herman JB, Brotman AW, Pollack MH, et al: Fluoxetine-induced sexual dysfunction. J Clin Psychiatry 51:25-27, 1990.
  27. Jacobsen FM: A double-blind placebo-controlled trial of yohimbine for treatment of SRI-induced sexual dysfunction. New Research Program and Abstracts of the Annual Meeting of the American Psychiatric Association, New York, 1996, p 266. Abstract NR716.
  28. Beasley CM, Bosomworth JC, Wernicke JK: Fluoxetine: Relationships among dose, response, adverse events, and plasma concentrations in the treatment of depression. Psychopharmacol Bull 26:18-24, 1990.
  29. Walker PW, Cole JO, Gardner EA, et al: Improvement in fluoxetine-associated sexual dysfunction in patients switched to bupropion. J Clin Psychiatry 54:459-465, 1993.
  30. Herran A, Palacios-Araus L, Vazquez-Barquero JL, et al: Sexual dysfunction associated with serotonin specific reuptake inhibitors. J Clin Psychopharmacol 17(1):67-68, 1997.
  31. Gitlin MJ, Suri R: Management of side-effects of SSRIs and newer antidepressants, in Balon R (ed): Practical Management of Psychotropic Drug Side-Effects. New York, Marcel Dekker. In press.
  32. Reimherr FW, Chouinard G, Cohn CK, et al: Antidepressant efficacy of sertraline: A double-blind, placebo- and amitriptyline-controlled multicenter comparison study in outpatients with major depression. J Clin Psychiatry 51(suppl B):S18-S27, 1990.
  33. Labbate LA, Grimes JB, Hines AH, et al: Sexual dysfunction induced by SRIs. Abstracts of the Annual Meeting of the American Psychiatric Association, San Diego, 1997, pp 15-16. Paper Session # 12.
  34. Ferguson JM, Shrivastava RK, Stahl SM, et al: Effect of double-blind treatment with nefazodone or sertraline on reemergence of sexual dysfunction in depressed patients. New Program and Abstracts of the Annual Meeting of the American Psychiatric Association, New York, 1996, p 164. Abstract NR358.
  35. Sovner R: Anorgasmia associated with imipramine but not desipramine: Case report. J Clin Psychiatry 44:346-346, 1983.
  36. Shen WW: Female orgasmic inhibition by amoxapine. Am J Psychiatry 139:1220-1221, 1982. Letter.
  37. Rothschild AJ: Selective serotonin reuptake inhibitor-induced sexual dysfunction: Efficacy of a drug holiday. Am J Psychiatry 152:1514-1516, 1995.
  38. Nemeth A, Arato M, Treuer T, et al: Treatment of fluvoxamine-induced anorgasmia with a partial drug holiday. Am J Psychiatry 153:1365, 1996.
  39. Balon R: Drug holidays to counter sexual dysfunction. Am J Psychiatry 153:1370-1371, 1996.
  40. Schatzberg AF, Haddad P, Kaplan EM, et al: Serotonin reuptake inhibitor discontinuation syndrome: A hypothetical definition. J Clinical Psychiatry 58(suppl 7):S5-S10, 1997.
  41. Coupland NJ, Bell CJ, Potokar JP: Serotonin reuptake inhibitor withdrawal. J Clin Psychopharmacol 16:356-362, 1996.
  42. Goldbloom DS, Kennedy SH: Adverse interaction of fluoxetine and cyproheptadine in two patients with bulimia nervosa. J Clin Psychiatry 52:261-262, 1991.
  43. McCormick S, Olin J, Brotman AW: Reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients. J Clin Psychiatry 51:383-384, 1990.
  44. Zajecka J, Fawcett J, Schaff M, et al: The role of serotonin in sexual dysfunction: Fluoxetine-associated orgasm dysfunction. J Clin Psychiatry 52:66-68, 1991.
  45. Feder R: Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients. J Clin Psychiatry 52:163-164, 1991.
  46. Katz RJ, Rosenthal M: Adverse interaction of cyproheptadine with serotonergic antidepressants. J Clin Psychiatry 55:314-315, 1994.
  47. Price J, Grunhaus LJ: Treatment of clomipramine-induced anorgasmia with yohimbine: A case report. J Clin Psychiatry 51:32-33, 1990.
  48. Zubieta JK, Demitrack MA: Depression after cyproheptadine: MAO treatment. Biol Psychiatry 31:1172-1178, 1992. Letter.
  49. Norden MJ: Buspirone treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors. Depression 2:109-112, 1994.
  50. Reynolds RD: Sertraline-induced anorgasmia treated with intermittent nefazodone. J Clin Psychiatry 58:89, 1997.
  51. Aizenberg D, Gur S, Zemishlany Z, et al: Mianserin, a 5-HT2a/2c and alpha 2 antagonist, in the treatment of sexual dysfunction induced by serotonin reuptake inhibitors. Clin Neuropharmacol 20(3):210-214, 1997.
  52. Balogh S, Hendricks SE, Kang J: Treatment of fluoxetine-induced anorgasmia with amantadine. J Clin Psychiatry 53:212-213, 1992. Letter.
  53. Shrivastava RK, Shrivastava S, Overweg N, et al: Amantadine in the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors. J Clin Psychopharmacol 15:83-84, 1993.
  54. Balon R: Intermittent amantadine for fluoxetine-induced anorgasmia. J Sex Marital Ther 22: 290-292, 1996.
  55. Bitran D, Hull EM: Pharmacological analysis of male rat sexual behavior. Neurosci Biobehav Rev 11:365-389, 1987.
  56. Segraves RT: Effects of psychotropic drugs on human erection and ejaculation. Arch Gen Psychiatry 46:275-284, 1989.
  57. Labbate LA, Pollack MH: Treatment of fluoxetine-induced sexual dysfunction with bupropion: A case report. Ann Clin Psychiatry 6:13-15, 1994.
  58. Ashton AK, Rosen RC: Bupropion as an antidote for serotonin reuptake inhibitor-induced sexual dysfunction: A retrospective study. J Clin Psychiatry 59:112-115, 1998.
  59. Kraupl TF: Loss of libido in depression. BMJ 1:305, 1972.
  60. Bartlik BD, Kaplan PM, Kocsis JH, et al: Stimulants for SSRIs-induced sexual dysfunction. New Research Program and Abstracts of the Annual Meeting of the American Psychiatric Association, New York, 1996, p 246. Abstract NR644.
  61. Gitlin MJ: Treatment of sexual side effects with dopaminergic agents. J Clin Psychiatry 56:24, 1995.
  62. Bartlik BD, Kaplan PM, Kaplan HS: Psychostimulants apparently reverse sexual dysfunction secondary to selective serotonin reuptake inhibitors. J Sex Marital Ther 21:264-271, 1995.
  63. Feighner JP, Herbstein J, Damlouji NF: Combined MAOI, TCA, and direct stimulant therapy of treatment-resistant depression. J Clin Psychiatry 46:206-209, 1985.
  64. Morales A, Condra M, Owen JA, et al: Is yohimbine effective in the treatment of organic impotence? Results of a controlled trial. J Urol 137:1168-1172, 1987.
  65. Nelson RP: Nonoperative management of impotence. J Urol 139:2-3, 1988.
  66. Reid K, Morales A, Harris C, et al: Double-blind trial of yohimbine in treatment of psychogenic impotence. Lancet 2:421-423, 1987.
  67. Hollander E, McCarley A: Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 53(6):207-209, 1992.
  68. Jacobsen FM: Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 53:119-122, 1992.
  69. Price J, Grunhaus LJ: Treatment of clomipramine-induced anorgasmia with yohimbine: A case report. J Clin Psychiatry 51:32-33, 1990.
  70. Gross MD: Reversal by bethanechol of sexual dysfunction caused by anticholinergic antidepressants. Am J Psychiatry 139:1193-1194, 1982.
  71. Sorscher SM, Dilsaver SC: Antidepressant-induced sexual dysfunction in men: Due to cholinergic blockade? J Clin Psychopharmacol 6:53-55, 1986.
  72. Wandzel L, Falicki Z: Reversal by bethanechol of imipramine-induced ejaculatory dysfunction. Am J Psychiatry 144:1243-1244, 1987. Letter.
  73. Yager J: Bethanechol chloride can reverse erectile and ejaculatory dysfunction induced by tricyclic antidepressants and mazindol: Case report. J Clin Psychiatry 47:210-211, 1986.
  74. Cohen AJ: Gingko biloba for drug-induced sexual dysfunction. Abstracts of the Annual Meeting of the American Psychiatric Association, San Diego, Calif., 1997, p 15.